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- Title
Synthesis and evaluation of c(RGDyK)-coupled superparamagnetic iron oxide nanoparticles for specific delivery of large amount of doxorubicin to tumor cell.
- Authors
Guo, Lin; Ding, Wence; Zheng, Li-Min
- Abstract
We synthesized c(RGDyK)-coupled superparamagnetic iron oxide nanoparticles for specific delivery of large amount of doxorubicin to α β integrin rich tumor cells (RDSP) by using a novel triplex hands coupling reagent tris-succinimidyl aminotriacetate and evaluated their structure, drug release, target cell uptake, and cytotoxic effects. Besides the high-trapping efficient for magnetic targeting, RDSP also has integrin α β targeting property. Moreover, RDSP shows a high-drug load ratio and can carry a large amount of doxorubicin to the target tumor cells. Compare with those of doxorubicin coupled DSP without peptide c(RGDyK) modification, RDSP shows an increase uptake by target tumor cells and stronger tumor cell cytotoxicity. This investigate provides an idiographic way for targeted delivery therapeutic agents to tumors with high efficiency and low-carrier toxicity.
- Subjects
SUPERPARAMAGNETIC materials; IRON oxide nanoparticles; DOXORUBICIN; CANCER cells; INTEGRINS; CELL-mediated cytotoxicity
- Publication
Journal of Nanoparticle Research, 2013, Vol 15, Issue 6, p1
- ISSN
1388-0764
- Publication type
Academic Journal
- DOI
10.1007/s11051-013-1720-4