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- Title
Polyvalent integrin antagonist-decorated superparamagnetic iron oxide nanoparticles for triggering apoptosis in human leukemia cancer cells.
- Authors
Say, Rıdvan; Yazar, Suzan; Uğur, Alper; Hür, Deniz; Denizli, Adil; Ersöz, Arzu
- Abstract
Integrin family members are the main mediators of cell adhesion to the extracellular matrix and active as intra- and extracellular signaling molecules in a variety of processes. They bind to their ligands by interacting with short amino acid sequences, that is, RGD (arginine-glycine-aspartic acid) sequence. RGD sequences have been used to enhance cell binding to artificial surfaces, so RGD mimics have been used to block integrin binding to its ligand. Integrin-ligand interactions are dependent on divalent cations, and Mg provide higher-affinity binding to ligand for many integrins. In this study, we have designed new integrin antagonists using methacryloyl amidoaspartic acid (MAASP) monomer-conjugated silanized super paramagnetic iron oxide nanoparticles (SPIONs, the size of the nanoparticles was verified with an average size of 32.6 nm) and poly(MAASP- co-EDMA) shell-decorated silanized SPIONs. Several mechanisms have been proposed to describe uptake of modified SPIONs into the cells, including receptor-mediated endocytosis. Our aim is to bind these modified SPIONs to the integrin-mediated aspartic acid ends of MAASP monomers and block integrin binding to their ligand.
- Subjects
INTEGRINS; MULTIVALENT molecules; SUPERPARAMAGNETIC materials; IRON oxide nanoparticles; APOPTOSIS; LEUKEMIA; CANCER cells; ENDOCYTOSIS
- Publication
Journal of Nanoparticle Research, 2013, Vol 15, Issue 1, p1
- ISSN
1388-0764
- Publication type
Academic Journal
- DOI
10.1007/s11051-012-1350-2