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- Title
Mesoporous silica-coated superparamagnetic particles prepared by pseudomorphic transformation and their application in purification of plasmid DNA.
- Authors
Yan, Feng; Sun, Lin; Li, Fubiao; Zhuang, Jiaqi; Wang, Hongliang; Yang, Wensheng
- Abstract
Mesoporous silica-coated superparamagnetic particles were prepared via pseudomorphic transformation of pre-made amorphous silica-coated FeO-polymer composite particles using n-cetyltrimethylammonium bromide (CTAB) and 1,3,5-trimethyl benzene (MES) as template. The mesoporous particles presented almost the same size, shape, and magnetic property as the original amorphous particles but an ordered mesoporous shell with wormhole-like pore structure. The pore size of the shells increased from 2.4 to 3.1 and 4.2 nm as the molar ratio of MES/CTAB increased from 0 to 1.0 and 1.5. DNA extraction experiments showed the mesoporous particles were qualified for purification of plasmid DNA from bacterial lysate. Graphical abstract: [Figure not available: see fulltext.]
- Subjects
MESOPOROUS materials; SILICA; SURFACE coatings; PARAMAGNETISM; PHASE transitions; CHEMICAL purification; DNA; PLASMIDS; NANOMEDICINE; BROMIDES
- Publication
Journal of Nanoparticle Research, 2011, Vol 13, Issue 12, p6613
- ISSN
1388-0764
- Publication type
Academic Journal
- DOI
10.1007/s11051-011-0569-7