The role of molecular mechanism of Ten-Eleven Translocation2 (TET2) family proteins in pathogenesis of cardiovascular diseases (CVDs).

Zadeh, Fatemeh Javaherforoosh; Akbari, Tooba; zayeri, Zeynab Deris; Samimi, Azin; Davari, Nader; Rezaeeyan, Hadi

Cardiovascular disease (CVD) is one of the most common diseases worldwide. The underlying pathogenesis of the disease has not yet been determined, but many factors have been identified. Tet methylcytosine dioxygenase 2 (TET2) is one of the epigenetic factors involved in regulating many genes. Therefore, based on the studies shown, this factor plays an important role in preventing the occurrence of CVD. TET2 has been shown to increase angiogenesis by expressing Robo4. It also increases the activity of Matrix metalloproteinases (MMPs) and stimulates the secretion of Vascular endothelial growth factor angiogenesis. On the other hand, it has been shown that TET2 regulates the expression of several genes and the development of the heart during the embryonic period due to its oxygenating role. TET2 has been shown to regulates the expression of the genes such as Ying Yang1 (YY1), Sox9b, Inhbaa and many other genes that ultimately lead to the differentiation of cardiomyocytes. On the other hand, it has been shown that some Long non coding RNA and MicroRNAs reduce TET2 expression and CVD. Finally, it is concluded that inducing TET2 expression can be a good therapeutic strategy to prevent or improve CVD.

VASCULAR endothelial growth factors; CARDIOVASCULAR diseases; PATHOLOGY; LINCRNA; MATRIX metalloproteinases; HEART development; DIOXYGENASES

Molecular Biology Reports, 2020, Vol 47, Issue 7, p5503

0301-4851

Academic Journal

10.1007/s11033-020-05602-4