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Title

Ferroptosis in organ ischemia–reperfusion injuries: recent advancements and strategies.

Authors

Luan, Xiaoyu; Chen, Peng; Miao, Longyu; Yuan, Xinying; Yu, Chaoqun; Di, Guohu

Abstract

Ferroptosis is a newly discovered type of regulated cell death participated in multiple diseases. Different from other classical cell death programs such as necrosis and apoptosis, ferroptosis involving iron-catalyzed lipid peroxidation is characterized by Fe2 accumulation and mitochondria alterations. The phenomenon of oxidative stress following organ ischemia–reperfusion (I/R) has recently garnered attention for its connection to the onset of ferroptosis and subsequent reperfusion injuries. This article provides a comprehensive overview underlying the mechanisms of ferroptosis, with a further focus on the latest research progress regarding interference with ferroptotic pathways in organ I/R injuries, such as intestine, lung, heart, kidney, liver, and brain. Understanding the links between ferroptosis and I/R injury may inform potential therapeutic strategies and targeted agents.

Subjects

CELL death; REPERFUSION injury; OXIDATIVE stress; APOPTOSIS; PEROXIDATION; LUNGS

Publication

Molecular & Cellular Biochemistry, 2025, Vol 480, Issue 1, p19

ISSN

0300-8177

Publication type

Academic Journal

DOI

10.1007/s11010-024-04978-2

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