Results
Title

Physico-chemical study of norfloxacin and metronidazole binary mixtures.

Authors

Salceanu, Daniela-Crina; Pincu, Elena; Bruni, Giovanna; Marini, Amedeo; Meltzer, Viorica

Abstract

The physico-chemical characterization of norfloxacin commercial sample (NF), norfloxacin anhydrous form A (NFanhA), norfloxacin pentahydrate (NF·5H2O) and metronidazole (MZ) has been carried out. It was determined that the commercial sample is a mixture of 74% anhydrous NF form A and 26% hemipentahydrate NF. From XRPD analysis, it was observed that after the water loss, NF·5H2O undergoes a solid-solid transition and is converting to NFanhA. Solid-liquid equilibrium for NFanhA-MZ and NF·5H2O-MZ binary systems has been investigated using differential scanning calorimetry, and simple eutectic point was observed, in good approximation, at 419 K for all the mixtures studied. The experimental solid-liquid phase diagram was compared with predictions obtained from available eutectic equilibrium models. The results indicate non-ideality for the mixture. The mixing enthalpy was determined at the eutectic composition and the negative value obtained, ΔM<italic>H</italic> = − 13.28 kJ mol−1, indicates that molecules of the two components form clusters in the eutectic melt.

Subjects

NORFLOXACIN; METRONIDAZOLE; BINARY mixtures; SOLID-liquid equilibrium; PHASE diagrams; ENTHALPY

Publication

Journal of Thermal Analysis & Calorimetry, 2018, Vol 132, Issue 2, p1095

ISSN

1388-6150

Publication type

Academic Journal

DOI

10.1007/s10973-017-6919-7