Title: Thermal characterization and compatibility studies of itraconazole and excipients for development of solid lipid nanoparticles.
Authors: Kumar, Neeraj; Goindi, Shishu; Saini, Balraj; Bansal, Gulshan
Abstract: The current study was performed to investigate possible interactions between triazole antifungal drug itraconazole (ITR) with selected excipients commonly used for development of solid lipid nanoparticles. The excipients included common lipids (glyceryl behenate (Compritol 888 ATO™), glyceryl monostearate, stearic acid, and cetyl palmitate), charge inducers (dicetyl phosphate and stearlyamine), and surfactants (sodium cholate and sodium deoxycholate). Differential scanning calorimetry, isothermal stress testing, Fourier transform infrared spectral analysis, optical microcopy, and X-ray powder diffraction analysis were performed for assessing the compatibility between the drug and the excipients. Results of the study suggest that the stearic acid exhibited drug-excipient interactions, whereas all other excipients used in the study were found to be compatible with ITR.
Subjects: ANTIFUNGAL agents; EXCIPIENTS; BIOCOMPATIBILITY; THERMAL analysis; NANOPARTICLES; MICROBIAL lipids; DIFFERENTIAL scanning calorimetry
Publication: Journal of Thermal Analysis & Calorimetry, 2014, Vol 115, Issue 3, p2375
ISSN: 1388-6150
Publication type: Academic Journal
DOI: 10.1007/s10973-013-3237-6

Thermal characterization and compatibility studies of itraconazole and excipients for development of solid lipid nanoparticles.

Kumar, Neeraj; Goindi, Shishu; Saini, Balraj; Bansal, Gulshan