Your institution may have access to this item. Find your institution then sign in to continue.

Title: Synthesis of 11-C-quetiapine, 11-C-isoclotiapine and 10-(4-methylpiperazin-1-yl)pyrido[4,3-b][1,4]benzothiazepine[10-C].
Authors: Saadatjoo, Naghi; Javaheri, Mohsen; Saemian, Nader; Amini, Mohsen
Abstract: Quetiapine is one of the most widely used antipsychotic drug which acts as an antagonist for multiple neurotransmitter receptor sites. 2-[2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy]ethanol (quetiapine ) labeled with carbon-14 in 11-position has been synthesized as part of a 5-step sequence from anthranilic acid-[carboxy-C]. We have presented a convenient synthetic pathway for labeling of quetiapine with carbon-14 by using one-pot procedures from a key thiazepin-11(10H)-one-[11-C] by good radiochemical yield. And also isoclotiapine[11-C], and 10-(4-methylpiperazin-1-yl)pyrido[4,3-b][1,4]benzothiazepine[10-C], synthesized according to this route.
Subjects: CHEMICAL synthesis; QUETIAPINE; ANTIPSYCHOTIC agents; CHEMICAL inhibitors; AMINOBENZOIC acids
Publication: Journal of Radioanalytical & Nuclear Chemistry, 2016, Vol 310, Issue 1, p433
ISSN: 0236-5731
Publication type: Academic Journal
DOI: 10.1007/s10967-016-4798-1

We found a match

Synthesis of 11-C-quetiapine, 11-C-isoclotiapine and 10-(4-methylpiperazin-1-yl)pyrido[4,3-b][1,4]benzothiazepine[10-C].