Title: Inhibition of oxygen consumption in skeletal muscle-derived mitochondria by pinacidil, diazoxide, and glibenclamide, but not by 5-hydroxydecanoate.
Abstract: The article discusses a study on the effects of specific KATP channel activators like pinacidil and diazoxide and the action of inhibitors like glibenclamide and 5-hydroxydecanoate (HD) on oxygen consumption in isolated mitochondria. Oxygen consumption was explored using isolated mitochondria of pectoralis muscle of 3-week-old Arbor Acres chickens. It suggests that above agents exert effects on skeletal-muscle mitochondria not related to their effects on mito-KATP channel.
Subjects: ANTIHYPERTENSIVE agents; INHIBITION of potassium channels; GLIBENCLAMIDE; MUSCLE mitochondria; OXYGEN consumption; PECTORALIS muscle
Publication: Journal of Bioenergetics & Biomembranes, 2010, Vol 42, Issue 1, p21
ISSN: 0145-479X
Publication type: Academic Journal
DOI: 10.1007/s10863-009-9265-z

Inhibition of oxygen consumption in skeletal muscle-derived mitochondria by pinacidil, diazoxide, and glibenclamide, but not by 5-hydroxydecanoate.

ANTIHYPERTENSIVE agents; INHIBITION of potassium channels; GLIBENCLAMIDE; MUSCLE mitochondria; OXYGEN consumption; PECTORALIS muscle