Zn-doped and (Zn Mn) co-doped CaCuTiO ceramics were prepared by the citrate-nitrate combustion derived powders in order to investigate the effect of dopants on the microstructure and electrical properties. The results showed that giant dielectric response was enhanced by co-doping of Zn and Mn. Compared with other samples, (Zn Mn) co-doped ceramics exhibit a fine-grained microstructure. Much stronger nonohmic properties were realized in these ceramics. It is significant that the (Zn Mn) co-doping effectively reduced the dielectric loss in the medium frequency region and at room temperature. At x = 0.05 and y = 0.03, low dielectric loss ~0.026 and moderate dielectric constant ~6620 were observed at room temperature and 10 kHz. The present results indicate that (Zn Mn) co-doping may improve the dielectric properties and increase the grain boundary resistance of CaCuTiO.