Why you should read Dr. Cramer's perspective.

Martin, Yvonne Connolly

The author reflects on the article of Doctor Richard Cramer regarding the results from the 22 years since the first publication of the three-dimensional (3D) quantitative structure-activity relationship (QSAR) method. She says that Cramer has shown the consideration of 3D properties of the ligand structures in a two-edged sword. She also notes that Cramer also focuses on the emphasis of Topomer comparative molecular field analysis (CoMFA) on modifications in the structure of the small molecule.

CRAMER, Richard; QSAR models; LIGANDS (Biochemistry); THREE-dimensional imaging; COMPARATIVE studies

Journal of Computer-Aided Molecular Design, 2011, Vol 25, Issue 3, p195

0920-654X

Academic Journal

10.1007/s10822-011-9414-4