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- Title
Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder.
- Authors
Casey, S; Carter, M; Looney, A M; Livingstone, V; Moloney, G; O'Keeffe, G W; Taylor, R S; Kenny, L C; McCarthy, F P; McCowan, L M E; Thompson, J M D; Murray, D M; SCOPE Consortium
- Abstract
Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p = 0.02), and 20 weeks (p = 0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment.
- Publication
Journal of autism and developmental disorders, 2022, Vol 52, Issue 9, p3919
- ISSN
1573-3432
- Publication type
Journal Article
- DOI
10.1007/s10803-021-05271-7