Works matching IS 01676997 AND DT 2020 AND VI 38 AND IP 3

Results: 32

Impact of neutrophil-to-lymphocyte ratio in patients with EGFR-mutant NSCLC treated with tyrosine kinase inhibitors.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 885, doi. 10.1007/s10637-020-00919-0

By:

Ono, Taihei;
Igawa, Satoshi;
Kurahayashi, Shintaro;
Okuma, Yuriko;
Sugimoto, Ai;
Kusuhara, Seiichiro;
Ozawa, Takahiro;
Fukui, Tomoya;
Sasaki, Jiichiro;
Mitsufuji, Hisashi;
Yokoba, Masanori;
Kubota, Masaru;
Katagiri, Masato;
Naoki, Katsuhiko

Publication type:

Article

Evaluation of the potential effect of dacomitinib, an EGFR tyrosine kinase inhibitor, on ECG parameters in patients with advanced non-small cell lung cancer.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 874, doi. 10.1007/s10637-019-00887-0

By:

Tan, Weiwei;
Giri, Nagdeep;
Quinn, Susan;
Wilner, Keith;
Parivar, Kourosh

Publication type:

Article

A pilot study on intermittent every other days of 5-dose Filgrastim compared with single Pegfilgrastim in breast Cancer patients receiving adjuvant Docetaxel, doxorubicin, and cyclophosphamide (TAC) chemotherapy.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 866, doi. 10.1007/s10637-019-00863-8

By:

Sohn, Byeong Seok;
Jeong, Jae Ho;
Ahn, Jin-Hee;
Jung, Kyung Hae;
Kim, Jeong Eun;
Sohn, Joo Hyuk;
Koh, Su-Jin;
Seo, Jae Hong;
Lee, Keun Seok;
Kim, Sung-Bae

Publication type:

Article

Stathmin 1 is highly expressed and associated with survival outcome in malignant adrenocortical tumours.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 899, doi. 10.1007/s10637-019-00846-9

By:

dos Santos Passaia, Bárbara;
Lima, Keli;
Kremer, Jean Lucas;
da Conceição, Barbara Brito;
de Paula Mariani, Beatriz Marinho;
da Silva, Jean Carlos Lipreri;
Zerbini, Maria Claudia Nogueira;
Fragoso, Maria Candida Barisson Villares;
Machado-Neto, João Agostinho;
Lotfi, Claudimara Ferini Pacicco

Publication type:

Article

Efficacy of immune checkpoint blockade in MUTYH-associated hereditary colorectal cancer.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 894, doi. 10.1007/s10637-019-00842-z

By:

Volkov, Nikita M.;
Yanus, Grigoriy A.;
Ivantsov, Alexandr O.;
Moiseenko, Fedor V.;
Matorina, Olga G.;
Bizin, Ilya V.;
Moiseyenko, Vladimir M.;
Imyanitov, Evgeny N.

Publication type:

Article

Phase 1 study of the MDM2 inhibitor AMG 232 in patients with advanced P53 wild-type solid tumors or multiple myeloma.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 831, doi. 10.1007/s10637-019-00840-1

By:

Gluck, W. Larry;
Gounder, Mrinal M.;
Frank, Richard;
Eskens, Ferry;
Blay, Jean Yves;
Cassier, Philippe A.;
Soria, Jean-Charles;
Chawla, Sant;
de Weger, Vincent;
Wagner, Andrew J.;
Siegel, David;
De Vos, Filip;
Rasmussen, Erik;
Henary, Haby A.

Publication type:

Article

Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects—results from the POUDER pilot study.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 776, doi. 10.1007/s10637-019-00826-z

By:

Lozanovski, Vladimir J.;
Polychronidis, Georgios;
Gross, Wolfgang;
Gharabaghi, Negin;
Mehrabi, Arianeb;
Hackert, Thilo;
Schemmer, Peter;
Herr, Ingrid

Publication type:

Article

Phase I study of the anti-endothelin B receptor antibody-drug conjugate DEDN6526A in patients with metastatic or unresectable cutaneous, mucosal, or uveal melanoma.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 844, doi. 10.1007/s10637-019-00832-1

By:

Sandhu, Shahneen;
McNeil, Catriona M.;
LoRusso, Patricia;
Patel, Manish R.;
Kabbarah, Omar;
Li, Chunze;
Sanabria, Sandra;
Flanagan, W. Michael;
Yeh, Ru-Fang;
Brunstein, Flavia;
Nazzal, Denise;
Hicks, Rodney;
Lemahieu, Vanessa;
Meng, Raymond;
Hamid, Omid;
Infante, Jeffrey R.

Publication type:

Article

Stimulation of neuroendocrine differentiation in prostate cancer cells by GHRH and its blockade by GHRH antagonists.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 746, doi. 10.1007/s10637-019-00831-2

By:

Muñoz-Moreno, Laura;
Carmena, María J.;
Schally, Andrew V.;
Prieto, Juan C.;
Bajo, Ana M.

Publication type:

Article

Phase 1b study of a small molecule antagonist of human chemokine (C-C motif) receptor 2 (PF-04136309) in combination with nab-paclitaxel/gemcitabine in first-line treatment of metastatic pancreatic ductal adenocarcinoma.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 800, doi. 10.1007/s10637-019-00830-3

By:

Noel, Marcus;
O'Reilly, Eileen M.;
Wolpin, Brian M.;
Ryan, David P.;
Bullock, Andrea J.;
Britten, Carolyn D.;
Linehan, David C.;
Belt, Brian A.;
Gamelin, Eric C.;
Ganguly, Bishu;
Yin, Donghua;
Joh, Tenshang;
Jacobs, Ira A.;
Taylor, Carrie T.;
Lowery, Maeve A.

Publication type:

Article

In vivo and in vitro inhibition of osteosarcoma growth by the pan Bcl-2 inhibitor AT-101.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 675, doi. 10.1007/s10637-019-00827-y

By:

Masuelli, Laura;
Benvenuto, Monica;
Izzi, Valerio;
Zago, Erika;
Mattera, Rosanna;
Cerbelli, Bruna;
Potenza, Vito;
Fazi, Sara;
Ciuffa, Sara;
Tresoldi, Ilaria;
Lucarelli, Enrico;
Modesti, Andrea;
Bei, Roberto

Publication type:

Article

Pharmacokinetic characteristics of vactosertib, a new activin receptor-like kinase 5 inhibitor, in patients with advanced solid tumors in a first-in-human phase 1 study.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 812, doi. 10.1007/s10637-019-00835-y

By:

Jung, Su Young;
Hwang, Sunjin;
Clarke, Jeffery M.;
Bauer, Todd M.;
Keedy, Vicki L.;
Lee, Hukeun;
Park, Neunggyu;
Kim, Seong-Jin;
Lee, Jangik I.

Publication type:

Article

A phase 1b dose escalation study of Wnt pathway inhibitor vantictumab in combination with nab-paclitaxel and gemcitabine in patients with previously untreated metastatic pancreatic cancer.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 821, doi. 10.1007/s10637-019-00824-1

By:

Davis, S. Lindsey;
Cardin, Dana B.;
Shahda, Safi;
Lenz, Heinz-Josef;
Dotan, Efrat;
O'Neil, Bert H.;
Kapoun, Ann M.;
Stagg, Robert J.;
Berlin, Jordan;
Messersmith, Wells A.;
Cohen, Steven J.

Publication type:

Article

Xanthan gum-based hydrogel containing nanocapsules for cutaneous diphenyl diselenide delivery in melanoma therapy.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 662, doi. 10.1007/s10637-019-00823-2

By:

Ferreira, Luana Mota;
Sari, Marcel Henrique Marcondes;
Azambuja, Juliana Hofstatter;
da Silveira, Elita Ferreira;
Cervi, Verônica Ferrari;
Marchiori, Marila Crivellaro Lay;
Maria-Engler, Silvya Stuchi;
Wink, Marcia Rosângela;
Azevedo, Jéssica Gonçalves;
Nogueira, Cristina Wayne;
Braganhol, Elizandra;
Cruz, Letícia

Publication type:

Article

Discovery of a novel rhein-SAHA hybrid as a multi-targeted anti-glioblastoma drug.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 755, doi. 10.1007/s10637-019-00821-4

By:

Chen, Jingkao;
Luo, Bingling;
Wen, Shijun;
Pi, Rongbiao

Publication type:

Article

Targeting ROS overgeneration by N-benzyl-2-nitro-1-imidazole-acetamide as a potential therapeutic reposition approach for cancer therapy.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 785, doi. 10.1007/s10637-019-00820-5

By:

Zeferino, Rodrigo C.;
Mota, Nádia S. R. S.;
Grinevicius, Valdelúcia M. A. S.;
Filipe, Karina B.;
Sulis, Paola M.;
Silva, Fátima R. M. B.;
Filho, Danilo W.;
Pich, Claus T.;
Pedrosa, Rozangela C.

Publication type:

Article

T cell cytotoxicity toward hematologic malignancy via B7-H3 targeting.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 722, doi. 10.1007/s10637-019-00819-y

By:

Sun, Xin;
Yu, Yang;
Ma, Li;
Xue, Xin;
Gao, Zhenkui;
Ma, Juan;
Zhang, Man

Publication type:

Article

A new BET inhibitor, 171, inhibits tumor growth through cell proliferation inhibition more than apoptosis induction.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 700, doi. 10.1007/s10637-019-00818-z

By:

Damaneh, Mohammadali Soleimani;
Hu, Jian-Ping;
Huan, Xia-Juan;
Song, Shan-Shan;
Tian, Chang-Qing;
Chen, Dan-Qi;
Meng, Tao;
Chen, Yue-Lei;
Shen, Jing-Kang;
Xiong, Bing;
Miao, Ze-Hong;
Wang, Ying-Qing

Publication type:

Article

Dual functionality of the antimicrobial agent taurolidine which demonstrates effective anti-tumor properties in pediatric neuroblastoma.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 690, doi. 10.1007/s10637-019-00816-1

By:

Swift, Lucy;
Zhang, Chunfen;
Kovalchuk, Olga;
Boklan, Jessica;
Trippett, Tanya;
Narendran, Aru

Publication type:

Article

Evaluation of absorption, distribution, metabolism, and excretion of [14C]-rucaparib, a poly(ADP-ribose) polymerase inhibitor, in patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 765, doi. 10.1007/s10637-019-00815-2

By:

Liao, Mingxiang;
Watkins, Simon;
Nash, Eileen;
Isaacson, Jeff;
Etter, Jeff;
Beltman, Jeri;
Fan, Rong;
Shen, Li;
Mutlib, Abdul;
Kemeny, Vendel;
Pápai, Zsuzsanna;
van Tilburg, Pascal;
Xiao, Jim J.

Publication type:

Article

Tetra-substituted pyrrole derivatives act as potent activators of p53 in melanoma cells.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 634, doi. 10.1007/s10637-019-00813-4

By:

Proto, Maria Chiara;
Fiore, Donatella;
Forte, Giovanni;
Cuozzo, Paola;
Ramunno, Anna;
Fattorusso, Caterina;
Gazzerro, Patrizia;
Pascale, Maria;
Franceschelli, Silvia

Publication type:

Article

Autophagy inhibition potentiates ruxolitinib-induced apoptosis in JAK2V617F cells.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 733, doi. 10.1007/s10637-019-00812-5

By:

Machado-Neto, João Agostinho;
Coelho-Silva, Juan Luiz;
Santos, Fábio Pires de Souza;
Scheucher, Priscila Santos;
Campregher, Paulo Vidal;
Hamerschlak, Nelson;
Rego, Eduardo Magalhães;
Traina, Fabiola

Publication type:

Article

Vitamin K3 thio-derivative: a novel specific apoptotic inducer in the doxorubicin-sensitive and -resistant cancer cells.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 650, doi. 10.1007/s10637-019-00810-7

By:

Hegazy, Mohamed-Elamir F.;
Fukaya, Masashi;
Dawood, Mona;
Yan, Ge;
Klinger, Anette;
Fleischer, Edmond;
Zaglool, Asmaa W.;
Efferth, Thomas

Publication type:

Article

Anticancer activity of a novel methylated analogue of L-mimosine against an in vitro model of human malignant melanoma.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 621, doi. 10.1007/s10637-019-00809-0

By:

Kyriakou, Sotiris;
Mitsiogianni, Melina;
Mantso, Theodora;
Cheung, William;
Todryk, Stephen;
Veuger, Stephany;
Pappa, Aglaia;
Tetard, David;
Panayiotidis, Mihalis I.

Publication type:

Article

A phase I study of AT-101, a BH3 mimetic, in combination with paclitaxel and carboplatin in solid tumors.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 855, doi. 10.1007/s10637-019-00807-2

By:

Stein, Mark N.;
Goodin, Susan;
Gounder, Murugeson;
Gibbon, Darlene;
Moss, Rebecca;
Portal, Daniella;
Lindquist, Diana;
Zhao, Yujie;
Takebe, Naoko;
Tan, Antoinette;
Aisner, Joseph;
Lin, Hongxia;
Ready, Neal;
Mehnert, Janice M.

Publication type:

Article

The influence of the coadministration of the p-glycoprotein modulator elacridar on the pharmacokinetics of lapatinib and its distribution in the brain and cerebrospinal fluid.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 574, doi. 10.1007/s10637-019-00806-3

By:

Karbownik, Agnieszka;
Sobańska, Katarzyna;
Płotek, Włodzimierz;
Grabowski, Tomasz;
Klupczynska, Agnieszka;
Plewa, Szymon;
Grześkowiak, Edmund;
Szałek, Edyta

Publication type:

Article

CKT0353, a novel microtubule targeting agent, overcomes paclitaxel induced resistance in cancer cells.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 584, doi. 10.1007/s10637-019-00803-6

By:

Dinić, Jelena;
Ríos-Luci, Carla;
Karpaviciene, Ieva;
Cikotiene, Inga;
Fernandes, Miguel X.;
Pešić, Milica;
Padrón, José M.

Publication type:

Article

Activation of IGF-1R pathway and NPM-ALK G1269A mutation confer resistance to crizotinib treatment in NPM-ALK positive lymphoma.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 599, doi. 10.1007/s10637-019-00802-7

By:

Li, Yanrong;
Wang, Kai;
Song, Na;
Hou, Kezuo;
Che, Xiaofang;
Zhou, Yang;
Liu, Yunpeng;
Zhang, Jingdong

Publication type:

Article

Effects of chemotherapy on placental development and function using in vitro culture of human primary cytotrophoblasts.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 547, doi. 10.1007/s10637-019-00800-9

By:

Depoix, Christophe Louis;
Colson, Arthur;
Mhallem-Gziri, Mina;
Hubinont, Corinne;
Debieve, Frederic

Publication type:

Article

LncRNA differentiation antagonizing non-protein coding RNA promotes proliferation and invasion through regulating miR-135a/NLRP37 axis in pancreatic cancer.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 714, doi. 10.1007/s10637-019-00798-0

By:

Tang, Yong;
Cao, Guojun;
Zhao, Gang;
Wang, Chunyou;
Qin, Qi

Publication type:

Article

Cotargeting the JAK/STAT signaling pathway and histone deacetylase by ruxolitinib and vorinostat elicits synergistic effects against myeloproliferative neoplasms.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 610, doi. 10.1007/s10637-019-00794-4

By:

Hao, Xing;
Xing, Wen;
Yuan, Jiajia;
Wang, Yingshao;
Bai, Jiaojiao;
Bai, Jie;
Zhou, Yuan

Publication type:

Article

Novel thiosemicarbazones induce high toxicity in estrogen-receptor-positive breast cancer cells (MCF7) and exacerbate cisplatin effectiveness in triple-negative breast (MDA-MB231) and lung adenocarcinoma (A549) cells.

Published in:

Investigational New Drugs, 2020, v. 38, n. 3, p. 558, doi. 10.1007/s10637-019-00789-1

By:

Medina-Reyes, Estefany Ingrid;
Mancera-Rodríguez, Marco Antonio;
Delgado-Buenrostro, Norma Laura;
Moreno-Rodríguez, Adriana;
Bautista-Martínez, Juan Luis;
Díaz-Velásquez, Clara Estela;
Martínez-Alarcón, Stefanía Andrea;
Torrens, Hugo;
de los Ángeles Godínez-Rodríguez, María;
Terrazas-Valdés, Luis Ignacio;
Chirino, Yolanda Irasema;
Vaca-Paniagua, Felipe

Publication type:

Article