Works matching IS 01676997 AND DT 2019 AND VI 37 AND IP 5

Results: 29

The antitumor efficacy of monomeric disintegrin obtustatin in S-180 sarcoma mouse model.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 1044, doi. 10.1007/s10637-019-00734-2

By:

Ghazaryan, Narine;
Movsisyan, Naira;
Macedo, Joana Catarina;
Vaz, Sara;
Ayvazyan, Naira;
Pardo, Luis;
Logarinho, Elsa

Publication type:

Article

Lopinavir-NO, a nitric oxide-releasing HIV protease inhibitor, suppresses the growth of melanoma cells in vitro and in vivo.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 1014, doi. 10.1007/s10637-019-00733-3

By:

Paskas, Svetlana;
Mazzon, Emanuela;
Basile, Maria Sofia;
Cavalli, Eugenio;
Al-Abed, Yousef;
He, Mingzhu;
Rakocevic, Sara;
Nicoletti, Ferdinando;
Mijatovic, Sanja;
Maksimovic-Ivanic, Danijela

Publication type:

Article

Bispecific anti-CD3 x anti-B7-H3 antibody mediates T cell cytotoxic ability to human melanoma in vitro and in vivo.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 1036, doi. 10.1007/s10637-018-00719-7

By:

Ma, Juan;
Shang, Tengfei;
Ma, Pan;
Sun, Xin;
Zhao, Jin;
Sun, Ximing;
Zhang, Man

Publication type:

Article

Biodistribution, pharmacokinetics and radioimmunotherapy of <sup>188</sup>Re-cetuximab in NCI-H292 human lung tumor-bearing nude mice.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 961, doi. 10.1007/s10637-018-00718-8

By:

Chang, Ya-Jen;
Ho, Chung-Li;
Cheng, Kai-Hung;
Kuo, Wan-I;
Lee, Wan-Chi;
Lan, Keng-Li;
Chang, Chih-Hsien

Publication type:

Article

A phase I study of the antibody drug conjugate ASG-5ME, an SLC44A4-targeting antibody carrying auristatin E, in metastatic castration-resistant prostate cancer.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 1052, doi. 10.1007/s10637-019-00731-5

By:

McHugh, Deaglan;
Eisenberger, Mario;
Heath, Elisabeth I.;
Bruce, Justine;
Danila, Daniel C.;
Rathkopf, Dana E.;
Feldman, Jarett;
Slovin, Susan F.;
Anand, Banmeet;
Chu, Rong;
Lackey, Jacqueline;
Reyno, Leonard;
Antonarakis, Emmanuel S.;
Morris, Michael J.

Publication type:

Article

Nifuroxazide induces apoptosis, inhibits cell migration and invasion in osteosarcoma.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 1006, doi. 10.1007/s10637-019-00724-4

By:

Luo, Yi;
Zeng, Anqi;
Fang, Aiping;
Song, Linjiang;
Fan, Chen;
Zeng, Chenjuan;
Ye, Tinghong;
Chen, Hao;
Tu, Chongqi;
Xie, Yongmei

Publication type:

Article

Human antigen R and drug resistance in tumors.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 1107, doi. 10.1007/s10637-018-00723-x

By:

Zhou, Fenghai;
Zhang, Fa;
Zhou, Chuan;
Liang, Mengtian;
Cai, Zhonglin;
Lv, Haidi;
Li, Wenjuan;
Wei, Xupan

Publication type:

Article

In vitro and in vivo cytotoxic activity and human serum albumin interaction for a methoxy-styryl-thiosemicarbazone.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 994, doi. 10.1007/s10637-018-00722-y

By:

Chaves, Otávio Augusto;
de Castro, Isabela S.;
Goulart, Carla Marins;
Bellieny, Myrtes S. S.;
Netto-Ferreira, José Carlos;
Echevarria-Lima, Juliana;
Echevarria, Aurea

Publication type:

Article

Modified ingenol semi-synthetic derivatives from Euphorbia tirucalli induce cytotoxicity on a large panel of human cancer cell lines.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 1029, doi. 10.1007/s10637-019-00728-0

By:

Silva, Viviane A. O;
Rosa, Marcela N.;
Martinho, Olga;
Tanuri, Amilcar;
Lima, João Paulo;
Pianowski, Luiz F.;
Reis, Rui M.

Publication type:

Article

The rhenium(I)-diselenoether anticancer drug targets ROS, TGF-β1, VEGF-A, and IGF-1 in an in vitro experimental model of triple-negative breast cancers.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 973, doi. 10.1007/s10637-019-00727-1

By:

Collery, Philippe;
Veena, Vijay;
Harikrishnan, Adhikesavan;
Desmaele, Didier

Publication type:

Article

Sensitization of colorectal cancer to irinotecan therapy by PARP inhibitor rucaparib.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 948, doi. 10.1007/s10637-018-00717-9

By:

Augustine, Titto;
Maitra, Radhashree;
Zhang, Jinghang;
Nayak, Jay;
Goel, Sanjay

Publication type:

Article

Significant differences on submission lag following regulation reform for registration of novel therapeutic drugs in Taiwan.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 1094, doi. 10.1007/s10637-018-00715-x

By:

Sun, I-Chen

Publication type:

Article

A phase I study of ontuxizumab, a humanized monoclonal antibody targeting endosialin, in Japanese patients with solid tumors.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 1061, doi. 10.1007/s10637-018-0713-7

By:

Doi, Toshihiko;
Aramaki, Takeshi;
Yasui, Hirofumi;
Muro, Kei;
Ikeda, Masafumi;
Okusaka, Takuji;
Inaba, Yoshitaka;
Nakai, Kenya;
Ikezawa, Hiroki;
Nakajima, Ryo

Publication type:

Article

The cellular effects of novel triazine nitrogen mustards in glioblastoma LBC3, LN-18 and LN-229 cell lines.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 984, doi. 10.1007/s10637-018-0712-8

By:

Krętowski, Rafał;
Drozdowska, Danuta;
Kolesińska, Beata;
Kamiński, Zbigniew;
Frączyk, Justyna;
Cechowska-Pasko, Marzanna

Publication type:

Article

Screening, identification of prostate cancer urinary biomarkers and verification of important spots.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 935, doi. 10.1007/s10637-018-0709-3

By:

Zhao, Huijun;
Zhao, Xuhong;
Lei, Ting;
Zhang, Man

Publication type:

Article

The availability of drug by liposomal drug delivery: Individual kinetics and tissue distribution of encapsulated and released drug in mice after administration of PEGylated liposomal prednisolone phosphate.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 890, doi. 10.1007/s10637-018-0708-4

By:

Smits, Evelien A. W.;
Soetekouw, José A.;
Pieters, Ebel H. E.;
Smits, Coen J. P.;
de Wijs-Rot, Nicolette;
Vromans, Herman

Publication type:

Article

Modulator of the PI3K/Akt oncogenic pathway affects mTOR complex 2 in human adenocarcinoma cells.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 902, doi. 10.1007/s10637-018-0705-7

By:

Curless, Blair P.;
Uko, Nne E.;
Matesic, Diane F.

Publication type:

Article

MICONIDINE acetate, a new selective and cytotoxic compound with synergic potential, induces cell cycle arrest and apoptosis in leukemia cells.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 912, doi. 10.1007/s10637-018-0694-6

By:

Maioral, Mariana Franzoni;
Stefanes, Natália Marceli;
Bigolin, Álisson;
Zatelli, Gabriele Andressa;
Philippus, Ana Cláudia;
de Barcellos Falkenberg, Miriam;
Santos-Silva, Maria Cláudia

Publication type:

Article

A mediator of phosphorylated Smad2/3, evodiamine, in the reversion of TAF-induced EMT in normal colonic epithelial cells.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 865, doi. 10.1007/s10637-018-0702-x

By:

Yang, Wanbin;
Gong, Xiuli;
Wang, Xiulian;
Huang, Chao

Publication type:

Article

Caffeic acid phenethyl ester exerts apoptotic and oxidative stress on human multiple myeloma cells.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 837, doi. 10.1007/s10637-018-0701-y

By:

Marin, Elizabeth Hernandez;
Paek, Hana;
Li, Mei;
Ban, Yesung;
Karaga, Marie Katie;
Shashidharamurthy, Rangaiah;
Wang, Xinyu

Publication type:

Article

The novel PI3K inhibitor S1 synergizes with sorafenib in non-small cell lung cancer cells involving the Akt-S6 signaling.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 828, doi. 10.1007/s10637-018-0698-2

By:

Wang, Juan;
Ma, Shumei;
Chen, Xiuhua;
Zhang, Sanqi;
Wang, Zhiyong;
Mei, Qibing

Publication type:

Article

MiR-181a, a new regulator of TGF-β signaling, can promote cell migration and proliferation in gastric cancer.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 923, doi. 10.1007/s10637-018-0695-5

By:

Ge, Shaohua;
Zhang, Haiyang;
Deng, Ting;
Sun, Wu;
Ning, Tao;
Fan, Qian;
Wang, Yi;
Wang, Xinyi;
Zhang, Qiumo;
Zhou, Zhengyang;
Yang, Haiou;
Ying, Guoguang;
Ba, Yi

Publication type:

Article

The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 849, doi. 10.1007/s10637-018-0704-8

By:

Kucinska, Malgorzata;
Mieszczak, Helena;
Piotrowska-Kempisty, Hanna;
Kaczmarek, Mariusz;
Granig, Walter;
Murias, Marek;
Erker, Thomas

Publication type:

Article

A novel tetravalent bispecific antibody targeting programmed death 1 and tyrosine-protein kinase Met for treatment of gastric cancer.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 876, doi. 10.1007/s10637-018-0689-3

By:

Hou, Weihua;
Yuan, Qingyun;
Yuan, Xingxing;
Wang, Yuxiong;
Mo, Wei;
Wang, Huijie;
Yu, Min

Publication type:

Article

Lurbinectedin (PM01183), a selective inhibitor of active transcription, effectively eliminates both cancer cells and cancer stem cells in preclinical models of uterine cervical cancer.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 818, doi. 10.1007/s10637-018-0686-6

By:

Yokoi, Eriko;
Mabuchi, Seiji;
Shimura, Kotaro;
Komura, Naoko;
Kozasa, Katsumi;
Kuroda, Hiromasa;
Takahashi, Ryoko;
Sasano, Tomoyuki;
Kawano, Mahiru;
Matsumoto, Yuri;
Kodama, Michiko;
Hashimoto, Kae;
Sawada, Kenjiro;
Kimura, Tadashi

Publication type:

Article

A novel humanized anti-PD-1 monoclonal antibody potentiates therapy in oral squamous cell carcinoma.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 799, doi. 10.1007/s10637-018-0678-6

By:

Cai, Y.;
Wang, Fei;
Liu, Q.;
Li, Z.;
Li, D.;
Sun, Z.

Publication type:

Article

Chemotherapy in pregnancy: exploratory study of the effects of paclitaxel on the expression of placental drug transporters.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 1075, doi. 10.1007/s10637-018-0677-7

By:

Berveiller, Paul;
Mir, Olivier;
Degrelle, Séverine A.;
Tsatsaris, Vassilis;
Selleret, Lise;
Guibourdenche, Jean;
Evain-Brion, Danièle;
Fournier, Thierry;
Gil, Sophie

Publication type:

Article

The drug lag and associated factors for orphan anticancer drugs in Japan compared to the United States.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 1086, doi. 10.1007/s10637-018-0612-y

By:

Nakayama, Hiroki;
Matsumaru, Naoki;
Tsukamoto, Katsura

Publication type:

Article

The bispecific anti-CD3 × anti-CD155 antibody mediates T cell immunotherapy for human prostate cancer.

Published in:

Investigational New Drugs, 2019, v. 37, n. 5, p. 810, doi. 10.1007/s10637-018-0683-9

By:

Zhao, Huijun;
Ma, Juan;
Lei, Ting;
Ma, Wanru;
Zhang, Man

Publication type:

Article