Works matching IS 01676997 AND DT 2017 AND VI 35 AND IP 2

Results: 15

Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ), a NQO1 bioactivatable molecule, in the domestic felid species.

Published in:

Investigational New Drugs, 2017, v. 35, n. 2, p. 134, doi. 10.1007/s10637-016-0414-z

By:

Lundberg, Alycen;
Francis, Joshua;
Pajak, Malgorzata;
Parkinson, Elizabeth;
Wycislo, Kathryn;
Rosol, Thomas;
Brown, Megan;
London, Cheryl;
Dirikolu, Levent;
Hergenrother, Paul;
Fan, Timothy

Publication type:

Article

Alofanib, an allosteric FGFR2 inhibitor, has potent effects on ovarian cancer growth in preclinical studies.

Published in:

Investigational New Drugs, 2017, v. 35, n. 2, p. 127, doi. 10.1007/s10637-016-0404-1

By:

Tyulyandina, Alexandra;
Harrison, Daniel;
Yin, Wei;
Stepanova, Evgenia;
Kochenkov, Dmitry;
Solomko, Eliso;
Peretolchina, Nina;
Daeyaert, Frits;
Joos, Jean-Baptiste;
Van Aken, Koen;
Byakhov, Mikhail;
Gavrilova, Evgenia;
Tjulandin, Sergei;
Tsimafeyeu, Ilya

Publication type:

Article

Sunitinib-paracetamol sex-divergent pharmacokinetics and tissue distribution drug-drug interaction in mice.

Published in:

Investigational New Drugs, 2017, v. 35, n. 2, p. 145, doi. 10.1007/s10637-016-0415-y

By:

Liew, Ming;
Ng, Salby;
Chew, Chii;
Koo, Teng;
Chee, Yun;
Chee, Evelyn;
Modamio, Pilar;
Fernández, Cecilia;
Mariño, Eduardo;
Segarra, Ignacio

Publication type:

Article

A phase 1 study of the pharmacokinetics of nucleoside analog trifluridine and thymidine phosphorylase inhibitor tipiracil (components of TAS-102) vs trifluridine alone.

Published in:

Investigational New Drugs, 2017, v. 35, n. 2, p. 189, doi. 10.1007/s10637-016-0409-9

By:

Cleary, James;
Rosen, Lee;
Yoshida, Kenichiro;
Rasco, Drew;
Shapiro, Geoffrey;
Sun, Weijing

Publication type:

Article

Zebrafish phenotypic screen identifies novel Notch antagonists.

Published in:

Investigational New Drugs, 2017, v. 35, n. 2, p. 166, doi. 10.1007/s10637-016-0423-y

By:

Velaithan, Vithya;
Okuda, Kazuhide;
Ng, Mei;
Samat, Norazwana;
Leong, Sze;
Faudzi, Siti;
Abas, Faridah;
Shaari, Khozirah;
Cheong, Sok;
Tan, Pei;
Patel, Vyomesh

Publication type:

Article

Phase I study of Nivolumab, an anti-PD-1 antibody, in patients with malignant solid tumors.

Published in:

Investigational New Drugs, 2017, v. 35, n. 2, p. 207, doi. 10.1007/s10637-016-0411-2

By:

Yamamoto, Noboru;
Nokihara, Hiroshi;
Yamada, Yasuhide;
Shibata, Takashi;
Tamura, Yosuke;
Seki, Yoshitaka;
Honda, Kazunori;
Tanabe, Yuko;
Wakui, Hiroshi;
Tamura, Tomohide

Publication type:

Article

Safety of raltegravir-based antiretroviral therapy in HIV-infected patients receiving multi-kinase inhibitors.

Published in:

Investigational New Drugs, 2017, v. 35, n. 2, p. 247, doi. 10.1007/s10637-016-0405-0

By:

Loulergue, Pierre;
Merad, Mansouria;
Coriat, Romain;
Ducreux, Michel;
Planchard, David;
Boige, Valérie;
Le Cesne, Axel;
Gregory, Thomas;
Poinsignon, Vianney;
Paci, Angelo;
Mir, Olivier

Publication type:

Article

Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2017, v. 35, n. 2, p. 180, doi. 10.1007/s10637-016-0407-y

By:

Beg, Muhammad;
Brenner, Andrew;
Sachdev, Jasgit;
Borad, Mitesh;
Kang, Yoon-Koo;
Stoudemire, Jay;
Smith, Susan;
Bader, Andreas;
Kim, Sinil;
Hong, David

Publication type:

Article

Targeting specificity protein 1 transcription factor and survivin using tolfenamic acid for inhibiting Ewing sarcoma cell growth.

Published in:

Investigational New Drugs, 2017, v. 35, n. 2, p. 158, doi. 10.1007/s10637-016-0417-9

By:

Shelake, Sagar;
Sankpal, Umesh;
Paul Bowman, W.;
Wise, Matthew;
Ray, Anish;
Basha, Riyaz

Publication type:

Article

Phase I clinical and pharmacokinetic study of PM01183 (a tetrahydroisoquinoline, Lurbinectedin) in combination with gemcitabine in patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2017, v. 35, n. 2, p. 198, doi. 10.1007/s10637-016-0410-3

By:

Paz-Ares, Luis;
Forster, Martin;
Boni, Valentina;
Szyldergemajn, Sergio;
Corral, Jesús;
Turnbull, Samantha;
Cubillo, Antonio;
Teruel, Carlos;
Calderero, Iker;
Siguero, Mariano;
Bohan, Patrick;
Calvo, Emiliano

Publication type:

Article

A phase II study of carboplatin plus weekly paclitaxel with bevacizumab for elderly patients with non-squamous non-small-cell lung cancer (NEJ016).

Published in:

Investigational New Drugs, 2017, v. 35, n. 2, p. 227, doi. 10.1007/s10637-017-0436-1

By:

Miura, Satoru;
Maemondo, Makoto;
Iwashima, Akira;
Harada, Toshiyuki;
Sugawara, Shunichi;
Kobayashi, Kunihiko;
Inoue, Akira;
Nakagawa, Taku;
Takiguchi, Yuichi;
Watanabe, Hiroshi;
Ishida, Takashi;
Terada, Masaki;
Kagamu, Hiroshi;
Gemma, Akihiko;
Yoshizawa, Hirohisa

Publication type:

Article

Erratum to: Zebrafish phenotypic screen identifies novel Notch antagonists.

Published in:

2017

By:

Velaithan, Vithya;
Okuda, Kazuhide;
Ng, Mei;
Samat, Norazwana;
Leong, Sze;
Faudzi, Siti;
Abas, Faridah;
Shaari, Khozirah;
Cheong, Sok;
Tan, Pei;
Patel, Vyomesh

Publication type:

Erratum

Phase II study of the antibody-drug conjugate TAK-264 (MLN0264) in patients with metastatic or recurrent adenocarcinoma of the stomach or gastroesophageal junction expressing guanylyl cyclase C.

Published in:

Investigational New Drugs, 2017, v. 35, n. 2, p. 235, doi. 10.1007/s10637-017-0439-y

By:

Almhanna, Khaldoun;
Miron, Maria;
Wright, David;
Gracian, Antonio;
Hubner, Richard;
Van Laethem, Jean-Luc;
López, Carolina;
Alsina, Maria;
Muñoz, Frederico;
Bendell, Johanna;
Firdaus, Irfan;
Messersmith, Wells;
Ye, Zhan;
Fasanmade, Adedigbo;
Danaee, Hadi;
Kalebic, Thea

Publication type:

Article

Erlotinib pharmacokinetics: a critical parameter influencing acute toxicity in elderly patients over 75 years-old.

Published in:

Investigational New Drugs, 2017, v. 35, n. 2, p. 242, doi. 10.1007/s10637-016-0400-5

By:

Bigot, Frederic;
Boudou-Rouquette, Pascaline;
Arrondeau, Jennifer;
Thomas-Schoemann, Audrey;
Tlemsani, Camille;
Chapron, Jeanne;
Huillard, Olivier;
Cessot, Anatole;
Vidal, Michel;
Alexandre, Jerome;
Blanchet, Benoit;
Goldwasser, Francois

Publication type:

Article

Phase I/II study of docetaxel combined with resminostat, an oral hydroxamic acid HDAC inhibitor, for advanced non-small cell lung cancer in patients previously treated with platinum-based chemotherapy.

Published in:

Investigational New Drugs, 2017, v. 35, n. 2, p. 217, doi. 10.1007/s10637-017-0435-2

By:

Tambo, Yuichi;
Hosomi, Yukio;
Sakai, Hiroshi;
Nogami, Naoyuki;
Atagi, Shinji;
Sasaki, Yasutsuna;
Kato, Terufumi;
Takahashi, Toshiaki;
Seto, Takashi;
Maemondo, Makoto;
Nokihara, Hiroshi;
Koyama, Ryo;
Nakagawa, Kazuhiko;
Kawaguchi, Tomoya;
Okamura, Yuta;
Nakamura, Osamu;
Nishio, Makoto;
Tamura, Tomohide

Publication type:

Article