Interactions Between Vitamin D and Calcium Intake, Vitamin D Receptor Genetic Polymorphisms, and Colorectal Cancer Risk.

Zhang, Xin; Fang, Yu-Jing; Feng, Xiao-Li; Abulimiti, Alinuer; Huang, Chu-Yi; Luo, Hong; Zhang, Cai-Xia

<bold>Background: </bold>Vitamin D has anticarcinogenic properties and acts through vitamin D receptor (VDR) to carry out its functions.<bold>Aims: </bold>This study explored the independent and combined effects of dietary vitamin D and calcium, and VDR genetic polymorphisms on colorectal cancer risk in a Chinese population.<bold>Methods: </bold>This ongoing case-control study recruited 488 cases with histologically confirmed colorectal cancer and 496 sex- and age-matched controls. Vitamin D and calcium intakes were assessed by a validated food frequency questionnaire, and VDR genotype was conducted for Fok I (rs2228570), Bsm I (rs1544410), Apa I (rs7975232), and Taq I (rs731236). Unconditional logistic regression was used to calculate odds ratio and 95% confidence interval after adjusting for various confounders.<bold>Results: </bold>No significant association was found between Fok I, Bsm I, Apa I, Taq I, and colorectal cancer risk. Higher intakes of dietary vitamin D and calcium were associated with 47% and 50% reduction in colorectal cancer risk. Significant interaction was observed between dietary vitamin D intake and Apa I polymorphisms in relation to colorectal cancer risk (Pinteraction = 0.006). Subjects with higher dietary vitamin D intake and mutant Apa I A allele had a substantially decreased risk of colorectal cancer compared to Apa I aa carriers with lower vitamin D intake.<bold>Conclusions: </bold>Our study supports that Apa I may interact with dietary vitamin D intake on colorectal cancer risk. However, no interactions were found between dietary vitamin D or calcium intakes and Fok I, Bsm I, and Taq I in relation to colorectal cancer risk.

VITAMIN D receptors; COLORECTAL cancer; DISEASE risk factors; VITAMIN D; GENETIC polymorphisms

Digestive Diseases & Sciences, 2021, Vol 66, Issue 6, p1895

0163-2116

Academic Journal

10.1007/s10620-020-06455-4