Follow-Up Study on CDX1 and CDX2 mRNA Expression in Noncancerous Gastric Mucosae After Helicobacter pylori Eradication.

Shin, Cheol; Kim, Nayoung; Chang, Hyun; Kim, Joo; Lee, Dong; Jung, Hyun; Shin, Cheol Min; Kim, Joo Sung; Lee, Dong Ho; Jung, Hyun Chae

Background: Changes in CDX1/CDX2 in gastric mucosae following Helicobacter pylori eradication have not been clarified yet.Aims: To evaluate the changes in CDX1/CDX2 expression after H. pylori eradication, in relation to the reversibility of intestinal metaplasia (IM).Methods: Time course of CDX1/CDX2 expressions was investigated in 176 subjects with various gastroduodenal disorders. Among them, 132 patients were H. pylori positives; H. pylori were eradicated in 107 of them; 13 failed to eradicate; and 12 did not receive H. pylori eradication therapy. Forty-four subjects were H. pylori negatives. Expression levels in CDX1 and CDX2 from noncancerous gastric mucosae of the corpus, as well as the histologic findings of gastric mucosae, were evaluated during the follow-up.Results: Average follow-up duration was 33.7 months (range 2-97 months). Expression levels in both CDX1 and CDX2 mRNAs were correlated with IM grade in the corpus (ρ = 0.633 and 0.554, respectively, all P 0.05). However, histologic improvement of IM at the corpus was associated with a decrease in CDX2 mRNA expression during the follow-up (linear mixed model, P for slope = 0.015).Conclusions: In this study, eradication of H. pylori did not show any beneficial effects on aberrant CDX1/CDX2 expressions or IM. Reversibility of IM may be associated with a decrease in CDX2 mRNA expression.

GASTRIC mucosa; HELICOBACTER pylori infections; MESSENGER RNA; GENE expression; BENIGN tumors; FOLLOW-up studies (Medicine); DISEASES; CANCER prevention; PROTEIN metabolism; RNA metabolism; CANCER; HELICOBACTER diseases; LONGITUDINAL method; METAPLASIA; DISEASE complications; STOMACH tumors; PREVENTION

Digestive Diseases & Sciences, 2016, Vol 61, Issue 4, p1051

0163-2116

Academic Journal

10.1007/s10620-016-4048-y