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Exposure-survival analyses of pazopanib in renal cell carcinoma and soft tissue sarcoma patients: opportunities for dose optimization.
Published in:
2017
By:
- Verheijen, R.;
- Swart, L.;
- Beijnen, J.;
- Schellens, J.;
- Huitema, A.;
- Steeghs, N.;
- Verheijen, R B;
- Swart, L E;
- Beijnen, J H;
- Schellens, J H M;
- Huitema, A D R
Publication type:
journal article
A comparison of limited sampling strategies for prediction of Ecteinascidin 743 clearance when administered as a 24-h infusion.
Published in:
2001
By:
- van Kesteren, Charlotte;
- Math&ocric;t, R. A. A.;
- López-Lázaro, L.;
- Cvitkovic, E.;
- Taamma, A.;
- Jimeno, J. M.;
- Guzman, C.;
- Schellens, J. H. M.;
- Misset, J. L.;
- Brain, E.;
- Hillebrand, M. J. X.;
- Rosing, H.;
- Beijnen, J. H.;
- van Kesteren, C;
- Mathĵt, R A;
- López-Lázaro, L;
- Schellens, J H;
- Hillebrand, M J
Publication type:
journal article
Pharmacokinetics and metabolism of docetaxel administered as a 1-h intravenous infusion.
Published in:
2000
By:
- Rosing, H.;
- Lustig, V.;
- Van Warmerdam, L. J. C.;
- Huizing, M. T.;
- Bokkel Huinink, W. W. Ten;
- Schellens, J. H. M.;
- Rodenhuis, S.;
- Bult, A.;
- Beijnen, J. H.;
- van Warmerdam, L J;
- ten Bokkel Huinink, W W;
- Schellens, J H
Publication type:
journal article
Clinical Pharmacokinetics of Vemurafenib in BRAF-Mutated Melanoma Patients.
Published in:
Journal of Clinical Pharmacology, 2017, v. 57, n. 1, p. 125, doi. 10.1002/jcph.788
By:
- Nijenhuis, C. M.;
- Huitema, A. D. R.;
- Blank, C.;
- Haanen, J. B. A. G.;
- Thienen, J. V.;
- Rosing, H.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article
From Mouse to Man: Predictions of Human Pharmacokinetics of Orally Administered Docetaxel From Preclinical Studies.
Published in:
Journal of Clinical Pharmacology, 2012, v. 52, n. 3, p. 370, doi. 10.1177/0091270010397051
By:
- Koolen, S. L. W.;
- van Waterschoot, R. A. B.;
- van Tellingen, O.;
- Schinkel, A. H.;
- Beijnen, J. H.;
- Schellens, J. H. M.;
- Huitema, A. D. R
Publication type:
Article
Pharmacodynamic modeling of adverse effects of anti-cancer drug treatment.
Published in:
European Journal of Clinical Pharmacology, 2016, v. 72, n. 6, p. 645, doi. 10.1007/s00228-016-2030-4
By:
- Vries Schultink, A.;
- Suleiman, A.;
- Schellens, J.;
- Beijnen, J.;
- Huitema, A.
Publication type:
Article
Evaluation of α-Integrin Expression as a Biomarker for Tumor Growth Inhibition for the Investigational Integrin Inhibitor E7820 in Preclinical and Clinical Studies.
Published in:
AAPS Journal, 2011, v. 13, n. 2, p. 230, doi. 10.1208/s12248-011-9260-2
By:
- Keizer, Ron;
- Funahashi, Y.;
- Semba, T.;
- Wanders, J.;
- Beijnen, J.;
- Schellens, J.;
- Huitema, A.
Publication type:
Article
Study protocols of three parallel phase 1 trials combining radical radiotherapy with the PARP inhibitor olaparib.
Published in:
2019
By:
- de Haan, R.;
- van Werkhoven, E.;
- van den Heuvel, M.M.;
- Peulen, H. M. U.;
- Sonke, G. S.;
- Elkhuizen, P.;
- van den Brekel, M. W. M.;
- Tesselaar, M. E. T.;
- Vens, C.;
- Schellens, J. H. M.;
- van Triest, B.;
- Verheij, M.
Publication type:
journal article
Determination of platinum surface contamination in veterinary and human oncology centres using inductively coupled plasma mass spectrometry.
Published in:
Veterinary & Comparative Oncology, 2015, v. 13, n. 3, p. 305, doi. 10.1111/vco.12049
By:
- Janssens, T.;
- Brouwers, E. E. M.;
- de Vos, J. P.;
- de Vries, N.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article
Inductively coupled plasma mass-spectrometric determination of platinum in excretion products of client-owned pet dogs.
Published in:
Veterinary & Comparative Oncology, 2015, v. 13, n. 2, p. 124, doi. 10.1111/vco.12025
By:
- Janssens, T.;
- Brouwers, E. E. M.;
- de Vos, J. P.;
- de Vries, N.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article
The performance of model-based versus rule-based phase I clinical trials in oncology.
Published in:
Journal of Pharmacokinetics & Pharmacodynamics, 2016, v. 43, n. 3, p. 235, doi. 10.1007/s10928-016-9466-0
By:
- Brummelen, E.;
- Huitema, A.;
- Werkhoven, E.;
- Beijnen, J.;
- Schellens, J.
Publication type:
Article
Quantitative analysis of connective tissue resorption in the supra-alveolar region of the mouse incisor ligament.
Published in:
Journal of Periodontal Research, 1982, v. 17, n. 4, p. 407, doi. 10.1111/j.1600-0765.1982.tb01171.x
By:
- Schellens, J. P. M.;
- Everts, V.;
- Beertsen, W.
Publication type:
Article
Quantification of docetaxel and its metabolites in human plasma by liquid chromatography/tandem mass spectrometry.
Published in:
Rapid Communications in Mass Spectrometry: RCM, 2013, v. 27, n. 17, p. 1925, doi. 10.1002/rcm.6654
By:
- Hendrikx, J. J. M. A.;
- Dubbelman, A. C.;
- Rosing, H.;
- Schinkel, A. H.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article
Phase I and pharmacological study of pazopanib in combination with oral topotecan in patients with advanced solid tumours.
Published in:
British Journal of Cancer, 2015, v. 113, n. 5, p. 706, doi. 10.1038/bjc.2015.257
By:
- Kerklaan, B Milojkovic;
- Lolkema, M P J;
- Devriese, L A;
- Voest, E E;
- Nol-Boekel, A;
- Mergui-Roelvink, M;
- Langenberg, M;
- Mykulowycz, K;
- Stoebenau, J;
- Lane, S;
- Legenne, P;
- Wissel, P;
- Smith, D A;
- Giantonio, B J;
- Schellens, J H M;
- Witteveen, P O
Publication type:
Article
HPV-negative squamous cell carcinoma of the anal canal is unresponsive to standard treatment and frequently carries disruptive mutations in TP53.
Published in:
British Journal of Cancer, 2015, v. 112, n. 8, p. 1358, doi. 10.1038/bjc.2015.20
By:
- Meulendijks, D;
- Tomasoa, N B;
- Dewit, L;
- Smits, P H M;
- Bakker, R;
- van Velthuysen, M-L F;
- Rosenberg, E H;
- Beijnen, J H;
- Schellens, J H M;
- Cats, A
Publication type:
Article
Chemoradiotherapy with capecitabine for locally advanced anal carcinoma: an alternative treatment option.
Published in:
British Journal of Cancer, 2014, v. 111, n. 9, p. 1726, doi. 10.1038/bjc.2014.467
By:
- Meulendijks, D;
- Dewit, L;
- Tomasoa, N B;
- van Tinteren, H;
- Beijnen, J H;
- Schellens, J H M;
- Cats, A
Publication type:
Article
Oral co-administration of elacridar and ritonavir enhances plasma levels of oral paclitaxel and docetaxel without affecting relative brain accumulation.
Published in:
British Journal of Cancer, 2014, v. 110, n. 11, p. 2669, doi. 10.1038/bjc.2014.222
By:
- Hendrikx, J J M A;
- Lagas, J S;
- Wagenaar, E;
- Rosing, H;
- Schellens, J H M;
- Beijnen, J H;
- Schinkel, A H
Publication type:
Article
Pharmacokinetically guided sunitinib dosing: a feasibility study in patients with advanced solid tumours.
Published in:
British Journal of Cancer, 2014, v. 110, n. 10, p. 2441, doi. 10.1038/bjc.2014.194
By:
- Lankheet, N A G;
- Kloth, J S L;
- Gadellaa-van Hooijdonk, C G M;
- Cirkel, G A;
- Mathijssen, R H J;
- Lolkema, M P J K;
- Schellens, J H M;
- Voest, E E;
- Sleijfer, S;
- de Jonge, M J A;
- Haanen, J B A G;
- Beijnen, J H;
- Huitema, A D R;
- Steeghs, N
Publication type:
Article
Prediction of early death among patients enrolled in phase I trials: development and validation of a new model based on platelet count and albumin.
Published in:
British Journal of Cancer, 2012, v. 107, n. 7, p. 1025, doi. 10.1038/bjc.2012.371
By:
- Ploquin, A;
- Olmos, D;
- Lacombe, D;
- A'Hern, R;
- Duhamel, A;
- Twelves, C;
- Marsoni, S;
- Morales-Barrera, R;
- Soria, J-C;
- Verweij, J;
- Voest, E E;
- Schöffski, P;
- Schellens, J H;
- Kramar, A;
- Kristeleit, R S;
- Arkenau, H-T;
- Kaye, S B;
- Penel, N
Publication type:
Article
A phase I study of E7080, a multitargeted tyrosine kinase inhibitor, in patients with advanced solid tumours.
Published in:
British Journal of Cancer, 2012, v. 106, n. 10, p. 1598, doi. 10.1038/bjc.2012.154
By:
- Boss, D S;
- Glen, H;
- Beijnen, J H;
- Keesen, M;
- Morrison, R;
- Tait, B;
- Copalu, W;
- Mazur, A;
- Wanders, J;
- O'Brien, J P;
- Schellens, J H M;
- Evans, T R J
Publication type:
Article
A multimarker QPCR-based platform for the detection of circulating tumour cells in patients with early-stage breast cancer.
Published in:
2011
By:
- Molloy, T. J.;
- Devriese, L. A.;
- Helgason, H. H.;
- Bosma, A. J.;
- Hauptmann, M.;
- Voest, E. E.;
- Schellens, J. H. M.;
- van't Veer, L. J.
Publication type:
journal article
Methotrexate area under the curve is an important outcome predictor in patients with primary CNS lymphoma: A pharmacokinetic-pharmacodynamic analysis from the IELSG no. 20 trial.
Published in:
2010
By:
- Joerger, M.;
- Huitema, A. D. R.;
- Krähenbühl, S.;
- Schellens, J. H. M.;
- Cerny, T.;
- Reni, M.;
- Zucca, E.;
- Cavalli, F.;
- Ferreri, A. J. M.;
- Krähenbühl, S
Publication type:
journal article
Phase I pharmacokinetic and pharmacodynamic study of the prenyl transferase inhibitor AZD3409 in patients with advanced cancer.
Published in:
2008
By:
- Appels, N. M. G. M.;
- Bolijn, M. J.;
- Chan, K.;
- Stephens, T. C.;
- Hoctin-Boes, G.;
- Middleton, M.;
- Beijnen, J. H.;
- de Bono, J. S.;
- Harris, A. L.;
- Schellens, J. H. M.
Publication type:
journal article
A dose-escalation study of indisulam in combination with capecitabine (Xeloda) in patients with solid tumours.
Published in:
2008
By:
- Siegel-Lakhai, W. S.;
- Zandvliet, A. S.;
- Huitema, A. D. R.;
- Tibben, M. M.;
- Milano, G.;
- Girre, V.;
- Diéras, V.;
- King, A.;
- Richmond, E.;
- Wanders, J.;
- Beijnen, J. H.;
- Schellens, J. H. M.;
- Diéras, V
Publication type:
journal article
The impact of FDA and EMEA guidelines on drug development in relation to Phase 0 trials.
Published in:
2007
By:
- Marchetti, S;
- Schellens, J H M
Publication type:
journal article
Phase II and pharmacological study of oral paclitaxel (Paxoral) plus ciclosporin in anthracycline-pretreated metastatic breast cancer.
Published in:
2006
By:
- Helgason, H. H.;
- Kruijtzer, C. M. F.;
- Huitema, A. D. R.;
- Marcus, S. G.;
- ten Bokkel Huinink, W. W.;
- Schot, M. E.;
- Schornagel, J. H.;
- Beijnen, J. H.;
- Schellens, J. H. M.
Publication type:
journal article
A novel self-microemulsifying formulation of paclitaxel for oral administration to patients with advanced cancer.
Published in:
British Journal of Cancer, 2006, v. 95, n. 6, p. 729, doi. 10.1038/sj.bjc.6603312
By:
- Veltkamp, S. A.;
- Thijssen, B.;
- Garrigue, J. S.;
- Lambert, G.;
- Lallemand, F.;
- Binlich, F.;
- Huitema, A. D. R.;
- Nuijen, B.;
- Nol, A.;
- Beijnen, J. H.;
- Schellens, J. H. M.
Publication type:
Article
Phase I and pharmacological study of the farnesyltransferase inhibitor tipifarnib (Zarnestra, R115777) in combination with gemcitabine and cisplatin in patients with advanced solid tumours.
Published in:
2005
By:
- Siegel-Lakhai, W. S.;
- Crul, M.;
- Zhang, S.;
- Sparidans, R. W.;
- Pluim, D.;
- Howes, A.;
- Solanki, B.;
- Beijnen, J. H.;
- Schellens, J. H. M.
Publication type:
journal article
Propofol extravasation in a breast cancer patient.
Published in:
2008
By:
- Huijbers, E. J. M.;
- Baars, J. W.;
- Schutte, P. F. E.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Case Study
Novel deoxycytidine kinase gene polymorphisms: a population screening study in Caucasian healthy volunteers.
Published in:
European Journal of Clinical Pharmacology, 2006, v. 62, n. 8, p. 681, doi. 10.1007/s00228-006-0162-7
By:
- Joerger, M.;
- Bosch, T. M.;
- Doodeman, V. D.;
- Beijnen, J. H.;
- Smits, P. H. M.;
- Schellens, J. H. M.
Publication type:
Article
Population pharmacokinetics and exploratory pharmacodynamics of ifosfamide and metabolites after a 72-h continuous infusion in patients with soft tissue sarcoma.
Published in:
European Journal of Clinical Pharmacology, 2001, v. 57, n. 6/7, p. 467, doi. 10.1007/s002280100322
By:
- Kerbusch, T.;
- Mathôt, R.;
- Keizer, H.;
- Ouwerkerk, J.;
- Rodenhuis, S.;
- Schellens, J.;
- Beijnen, J.
Publication type:
Article
Pharmacokinetics of oral cyclosporin A when co-administered to enhance the absorption of orally administered docetaxel.
Published in:
European Journal of Clinical Pharmacology, 2001, v. 57, n. 4, p. 305, doi. 10.1007/s002280100315
By:
- Malingré, M. M.;
- Ten Bokkel Huinink, W. W.;
- Mackay, M.;
- Schellens, J. H M.;
- Beijnen, J. H.
Publication type:
Article
Interactions of Serum Albumin, Valproic Acid and Carbamazepine with the Pharmacokinetics of Phenytoin in Cancer Patients.
Published in:
Basic & Clinical Pharmacology & Toxicology, 2006, v. 99, n. 2, p. 133, doi. 10.1111/j.1742-7843.2006.pto_309.x
By:
- Joerger, Markus;
- Huitema, A. D. R.;
- Boogerd, W.;
- van der Sande, J. J.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article
Quantitative analysis of gemcitabine triphosphate in human peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.
Published in:
Journal of Mass Spectrometry, 2006, v. 41, n. 12, p. 1633, doi. 10.1002/jms.1133
By:
- Veltkamp, S. A.;
- Hillebrand, M. J. X.;
- Rosing, H.;
- Jansen, R. S.;
- Wickremsinhe, E. R.;
- Perkins, E. J.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article
Sensitive inductively coupled plasma mass spectrometry assay for the determination of platinum originating from cisplatin, carboplatin, and oxaliplatin in human plasma ultrafiltrate.
Published in:
Journal of Mass Spectrometry, 2006, v. 41, n. 9, p. 1186, doi. 10.1002/jms.1087
By:
- Brouwers, E. E. M.;
- Tibben, M. M.;
- Rosing, H.;
- Hillebrand, M. J. X.;
- Joerger, M.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article
Quantitative analysis of ES-285, an investigational marine anticancer drug, in human, mouse, rat, and dog plasma using coupled liquid chromatography and tandem mass spectrometry.
Published in:
Journal of Mass Spectrometry, 2003, v. 38, n. 5, p. 548, doi. 10.1002/jms.469
By:
- Stokvis, E.;
- Nan-Offeringa, L.;
- Rosing, H.;
- López-Lázaro, L.;
- Aceña, J. L.;
- Miranda, E.;
- Lyubimov, A.;
- Levine, B. S.;
- D'Aleo, C.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article
Cost-effectiveness of monitoring endoxifen levels in breast cancer patients adjuvantly treated with tamoxifen.
Published in:
Breast Cancer Research & Treatment, 2018, v. 172, n. 1, p. 143, doi. 10.1007/s10549-018-4886-8
By:
- van Nuland, M.;
- Vreman, R. A.;
- ten Ham, R. M. T.;
- de Vries Schultink, A. H. M.;
- Rosing, H.;
- Schellens, J. H. M.;
- Beijnen, J. H.;
- Hövels, A. M.
Publication type:
Article
Use of dried blood spots for the determination of serum concentrations of tamoxifen and endoxifen.
Published in:
Breast Cancer Research & Treatment, 2014, v. 146, n. 1, p. 137, doi. 10.1007/s10549-014-2999-2
By:
- Jager, N.;
- Rosing, H.;
- Schellens, J.;
- Beijnen, J.;
- Linn, S.
Publication type:
Article
Tamoxifen dose and serum concentrations of tamoxifen and six of its metabolites in routine clinical outpatient care.
Published in:
Breast Cancer Research & Treatment, 2014, v. 143, n. 3, p. 477, doi. 10.1007/s10549-013-2826-1
By:
- Jager, N.;
- Rosing, H.;
- Schellens, J.;
- Linn, S.;
- Beijnen, J.
Publication type:
Article
Time-dependent resource use and costs associated with different states of disease in patients diagnosed with HER-2-positive metastatic breast cancer.
Published in:
Breast Cancer Research & Treatment, 2013, v. 139, n. 2, p. 489, doi. 10.1007/s10549-013-2532-z
By:
- Frederix, G.;
- Severens, J.;
- Hövels, A.;
- van Hasselt, J.;
- Raaijmakers, J.;
- Schellens, J.
Publication type:
Article
Importance of highly selective LC-MS/MS analysis for the accurate quantification of tamoxifen and its metabolites: focus on endoxifen and 4-hydroxytamoxifen.
Published in:
2012
By:
- Jager, N.;
- Rosing, H.;
- Linn, S.;
- Schellens, J.;
- Beijnen, J.
Publication type:
Report
Dosing oxaliplatin in a haemodialysis patient with metastatic rectum cancer monitored by free platinum concentrations.
Published in:
Journal of Clinical Pharmacy & Therapeutics, 2018, v. 43, n. 4, p. 574, doi. 10.1111/jcpt.12661
By:
- van Berlo – van de Laar, I. R. F.;
- Brummelhuis, W. J.;
- Imholz, A. L. T.;
- Schellens, J. H.;
- Huitema, A. D. R.;
- Jansman, F. G. A.
Publication type:
Article
Pharmacogenetic Screening for Polymorphisms in Drug-Metabolizing Enzymes and Drug Transporters in a Dutch Population.
Published in:
Molecular Diagnosis & Therapy, 2006, v. 10, n. 3, p. 175, doi. 10.1007/BF03256456
By:
- Bosch, T. M.;
- Doodeman, V. D.;
- Smits, P. H. M.;
- Meijerman, I.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article
Development and validation of a liquid chromatography–tandem mass spectrometry analytical method for the therapeutic drug monitoring of eight novel anticancer drugs.
Published in:
Biomedical Chromatography, 2018, v. 32, n. 4, p. 1, doi. 10.1002/bmc.4147
By:
- Herbrink, M.;
- de Vries, N.;
- Rosing, H.;
- Huitema, A. D. R.;
- Nuijen, B.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article
Development and validation of a LC-MS/MS method for the in vitro analysis of 1-hydroxymidazolam in human liver microsomes: application for determining CYP3A4 inhibition in complex matrix mixtures.
Published in:
Biomedical Chromatography, 2013, v. 27, n. 9, p. 1107, doi. 10.1002/bmc.2913
By:
- Mooiman, K. D.;
- Maas‐Bakker, R. F.;
- Rosing, H.;
- Beijnen, J. H.;
- Schellens, J. H. M.;
- Meijerman, I.
Publication type:
Article
Method development and validation for the quantification of dasatinib, erlotinib, gefitinib, imatinib, lapatinib, nilotinib, sorafenib and sunitinib in human plasma by liquid chromatography coupled with tandem mass spectrometry.
Published in:
Biomedical Chromatography, 2013, v. 27, n. 4, p. 466, doi. 10.1002/bmc.2814
By:
- Lankheet, N. A. G.;
- Hillebrand, M. J. X.;
- Rosing, H.;
- Schellens, J. H. M.;
- Beijnen, J. H.;
- Huitema, A. D. R.
Publication type:
Article
Quantitative analysis of docetaxel in human plasma using liquid chromatography coupled with tandem mass spectrometry.
Published in:
Biomedical Chromatography, 2005, v. 19, n. 5, p. 355, doi. 10.1002/bmc.457
By:
- Kuppens, I. E. L. M.;
- van Maanen, M. J.;
- Rosing, H.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article
Switching from an analogous to a stable isotopically labeled internal standard for the LC-MS/MS quantitation of the novel anticancer drug Kahalalide F significantly improves assay performance.
Published in:
Biomedical Chromatography, 2004, v. 18, n. 6, p. 400, doi. 10.1002/bmc.392
By:
- Stokvis, E.;
- Rosing, H.;
- López-Lázaro, L.;
- Schellens, J. H. M.;
- Beijnen, J. H.
Publication type:
Article
Monitoring of EGFR mutations in circulating tumor DNA of non-small cell lung cancer patients treated with EGFR inhibitors.
Published in:
2021
By:
- Verheijen, R. B.;
- van Duijl, T. T.;
- van den Heuvel, M. M.;
- Vessies, D.;
- Muller, M.;
- Beijnen, J. H.;
- Janssen, J. M.;
- Schellens, J. H. M.;
- Steeghs, N.;
- van den Broek, D.;
- Huitema, A. D. R.
Publication type:
journal article
Correction to: Exposure-survival analyses of pazopanib in renal cell carcinoma and soft tissue sarcoma patients: opportunities for dose optimization.
Published in:
2020
By:
- Verheijen, R. B.;
- Swart, E. L.;
- Beijnen, J. H.;
- Schellens, J. H. M.;
- Huitema, A. D. R.;
- Steeghs, N.
Publication type:
Correction Notice

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