Title: Recombinant human Cyclophilin A stimulates hair follicle cells via Wnt/β-catenin signaling pathway.
Authors: Kim, Kiyoon; Choe, Wonchae
Abstract: Objectives: To explore potential effects of recombinant peptidyl-prolyl isomerase human Cyclophilin A (CypA) in the growth of mouse hair and human hair follicle dermal papilla cells (HDP). Results: The hair growth of 8-weeks C57BL/6 mouse was significantly stimulated by recombinant human CypA protein. CypA also promoted Human Dermal Papilla (HDP) cell growth and induced β-catenin protein through GSK3β inhibition. Conclusions: The molecular chaperone CypA stimulates hair follicle and HDP cells through Wnt/β-catenin signaling pathway, suggesting that it might be a key molecule for hair loss disorder therapy.
Subjects: HAIR follicles; HAIR cells; CYCLOPHILINS; MOLECULAR chaperones; ISOMERASES; HAIR growth; KERATIN; WNT proteins
Publication: Biotechnology Letters, 2019, Vol 41, Issue 12, p1451
ISSN: 0141-5492
Publication type: Academic Journal
DOI: 10.1007/s10529-019-02751-w

Recombinant human Cyclophilin A stimulates hair follicle cells via Wnt/β-catenin signaling pathway.

Kim, Kiyoon; Choe, Wonchae