Title: Expression of Macrophage Colony-Stimulating Factor CSF-1 in Spinal Cord Neurons in Mice with Experimental Autoimmune Encephalomyelitis.
Authors: Balashov, A. V.; Balashov, V. P.; Shikhanov, N. P.; Gushchina, S. V.
Abstract: In mice with acute and chronic models of experimental autoimmune encephalomyelitis (EAE), a quantitative study of the dynamics of CSF-1 and IL-34 protein levels in the spinal cord and blood plasma was conducted by ELISA and the specificity of CSF-1 expression in spinal cord cells was examined by immunohistological methods. A significant increase in the level of CSF-1 in the spinal cord was detected and populations of motoneurons with intense CSF-1 immunoreactivity were identified in mice with acute and chronic EAE. The obtained results suggest a possible role of CSF-1 in the pathogenesis and progression of EAE/multiple sclerosis.
Subjects: MACROPHAGE colony-stimulating factor; MOTOR neurons; SPINAL cord; CORD blood; BLOOD plasma
Publication: Bulletin of Experimental Biology & Medicine, 2024, Vol 177, Issue 5, p682
ISSN: 0007-4888
Publication type: Academic Journal
DOI: 10.1007/s10517-024-06249-y

Expression of Macrophage Colony-Stimulating Factor CSF-1 in Spinal Cord Neurons in Mice with Experimental Autoimmune Encephalomyelitis.

Balashov, A. V.; Balashov, V. P.; Shikhanov, N. P.; Gushchina, S. V.