Results
Title

The Effect of the Toxic Dose of Baclofen on Selected Parameters of the Cardiovascular and Respiratory Systems.

Authors

Romanova, O. L.; Blagonravov, M. L.; Torshin, V. I.; Dzhuvalyakov, P. G.; Ershov, A. V.; Kislov, M. A.; Magulaev, A. M.

Abstract

The effect of the toxic dose of the muscle relaxant baclofen on the parameters of the cardiovascular and respiratory systems was studied in adult male Wistar rats (n=20). Systolic and diastolic BP, HR, and respiratory rate were measured; histological changes in the lungs 3, 4.5, and 24 h after drug administration. Baclofen was administered orally in a sublethal toxic dose of 85 mg/kg under anesthesia. Cardiac activity was analyzed using RSM physiological indicators monitoring system with MouseMonitor S (Indus Instruments) software. Histological examination was performed by light microscopy. Baclofen significantly decreased the respiratory rate and increased HR and BP. Histological examination of the lungs revealed a complex of general pathological processes, such as local circulatory disorders (venular and capillary fullness, sludge), leukocyte infiltration of the interalveolar septa and their thickening due to edema. These findings can be used to estimate the time elapsed after baclofen treatment.

Subjects

RESPIRATORY organs; BACLOFEN; CARDIOVASCULAR system; BLOOD circulation disorders; MUSCLE relaxants; PATIENT monitoring; LABORATORY rats

Publication

Bulletin of Experimental Biology & Medicine, 2023, Vol 175, Issue 6, p777

ISSN

0007-4888

Publication type

Academic Journal

DOI

10.1007/s10517-023-05945-5