Title: Functioning of the Antioxidant Defense System in Rotenone-Induced Parkinson's Disease.
Authors: Kryl'skii, E. D.; Razuvaev, G. A.; Potapova, T. N.; Akinina, A. I.; Nihaev, L. E.
Abstract: A comprehensive study of the functioning of antioxidant system in rats with rotenone-induced parkinsonism was conducted. The development of pathology led to inhibition of the majority of the studied antioxidant enzymes in the brain and blood serum of animals, which can be associated with decompensation of oxidative stress under conditions of prolonged mitochondrial dysfunction. These changes apparently make an important contribution into neuronal degeneration in the cerebral cortex and striatum and motor disorders in experimental animals.
Subjects: PARKINSON'S disease; ANTIOXIDANTS; MOVEMENT disorders; CEREBRAL cortex; OXIDATIVE stress; MOTOR cortex; LABORATORY animals
Publication: Bulletin of Experimental Biology & Medicine, 2021, Vol 171, Issue 6, p716
ISSN: 0007-4888
Publication type: Academic Journal
DOI: 10.1007/s10517-021-05302-4

Functioning of the Antioxidant Defense System in Rotenone-Induced Parkinson's Disease.

Kryl'skii, E. D.; Razuvaev, G. A.; Potapova, T. N.; Akinina, A. I.; Nihaev, L. E.