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- Title
Analysis of Antitumor Activity of the Liposomal Photosensitizer Lipophthalocyan.
- Authors
Lantsova, A. V.; Borisova, L. M.; Meerovich, G. A.; Bunyatyan, N. D.; Olefir, Yu. V.; Prokof'ev, A. B.; Evteev, V. A.; Sapovskii, M. M.; Kiseleva, M. P.; Sanarova, E. V.; Orlova, O. L.; Dmitrieva, M. V.; Polozkova, A. P.; Oborotova, N. A.; Ogay, M. A.; Khadzhieva, Z. J.; Nikolaeva, L. L.
- Abstract
We studied specific antitumor activity of a liposomal drug based on tetra-3-phenylthiophthalocyanine aluminum hydroxide (lipophthalocyan) intended for photodynamic therapy. The optimal dose and protocol for photodynamic therapy with lipophthalocyan were chosen in experiments on mice: single intravenous dose of 6 mg/kg with a 5-h interval between administration and laser exposure and irradiation energy density of 400 J/cm2. A wide spectrum antitumor activity of lipophthalocyan was demonstrated in vivo for various transplantable mouse tumors (Lewis lung epidermoid carcinoma, S37 sarcoma, and colon adenocarcinoma AKATOL). The results show the possibility of using lipophthalocyan for photodynamic therapy of tumors of surface localization (skin and mucosa tumors).
- Subjects
PHOTODYNAMIC therapy; PHOTOSENSITIZERS; SKIN tumors; ALUMINUM hydroxide; ENERGY density; MUCOUS membranes
- Publication
Bulletin of Experimental Biology & Medicine, 2020, Vol 168, Issue 3, p361
- ISSN
0007-4888
- Publication type
Academic Journal
- DOI
10.1007/s10517-020-04709-9