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Title: Visualization and Cytotoxicity of Fluorescence-Labeled Dimeric Magnetite-Gold Nanoparticles Conjugated with Prostate-Specific Membrane Antigen in Mouse Macrophages.
Authors: Pirutin, S. K.; Efremova, M. V.; Yusipovich, A. I.; Turovetskii, V. B.; Maksimov, G. V.; Druzhko, A. B.; Mazhuga, A. G.
Abstract: We demonstrated the possibility of penetration of magnetite-gold nanoparticles conjugated with prostate-specific membrane antigen into mouse macrophages. It was found that after 3-h incubation with nanoparticles in a concentration of 15 mg/liter at 37oC, they were seen in only 13% macrophages. In about 90% cells, the nanoparticles were detected within the cytoplasm. Under these conditions, membrane damage was revealed in 25% cells. These results should be taken into account in further development and application of nanomaterials for diagnostic and therapeutic purposes in oncology.
Subjects: MACROPHAGES; NANOPARTICLES; VISUALIZATION; MICE; NANOSTRUCTURED materials; MAGNETITE
Publication: Bulletin of Experimental Biology & Medicine, 2019, Vol 166, Issue 6, p386
ISSN: 0007-4888
Publication type: Academic Journal
DOI: 10.1007/s10517-019-04356-9

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Visualization and Cytotoxicity of Fluorescence-Labeled Dimeric Magnetite-Gold Nanoparticles Conjugated with Prostate-Specific Membrane Antigen in Mouse Macrophages.