Collagen Hydrolysis Products Reduce the Formation of Stress-Induced Ulcers by Regulating Stress-Associated Activation of the Neuroendocrine and Immune Systems.

Bakaeva, Z. V.; Ermakova, N. V.; Mankaeva, O. V.; Sveshnikov, D. S.; Severin, A. E.; Sinel’nikova, A. N.; Starshinov, Yu. P.; Radysh, I. V.; Torshin, V. I.; Frolov, D. A.; Kozlov, I. G.

We studied the effect of collagen fragments (PGP and AcPGP) on serum content of epinephrine, corticosterone, and IL-1β in rats subjected to water-immersion stress. The degree of local inflammation accompanying ulceration was assessed by IL-1β production by ln. gastricus caudalis cells. In 1 h, the sharp increase in hormone concentrations in the blood of stressed animals reflected the high stress intensity. Intranasal administration of PGP reduced the area of stress-induced ulcers by 63%, prevented the increase in the levels of stress hormones and the main proinflammatory cytokine in rat blood. The concentrations of IL-1β in cell culture from regional lymph node of experimental animals returned to normal in 24 and 48 h after the stress. Acetylation of PGP prevents with gastroprotection, but does not abrogate other properties of the peptide.

COLLAGEN; HYDROLYSIS; ULCERS; NEUROENDOCRINE system; IMMUNE system; WATER immersion; LYMPH nodes

Bulletin of Experimental Biology & Medicine, 2018, Vol 165, Issue 4, p449

0007-4888

Academic Journal

10.1007/s10517-018-4191-x