Results
Title

Acetylsalicylic Acid Produces Different Effects on the Production of Active Oxygen Species by Activated Platelets in Different Inflammatory Diseases.

Authors

Gabbasov, Z.; Kogan-Yasny, V.; Lakhno, D.; Kagan, L.; Ryzhkova, E.; Vasilieva, E.; Shpektor, A.

Abstract

We studied the effect of acetylsalicylic acid on ROS generation by platelets in patients after surgical interventions and in patients with bronchial asthma was studied. Platelets stimulated with platelet-activating factor are characterized by weak luminol-enhanced chemiluminescence in healthy people and patients after operations with laparoscopic incisions. Addition of platelet activation factor to platelet samples from patients after open abdominal surgery caused intensive chemiluminescence that was suppressed after platelet incubation with acetylsalicylic acid. At the same time, platelets of patients with aspirin-sensitive asthma did not respond to addition of platelet activating factor, but after incubation with acetylsalicylic acid, an intensive burst of chemiluminescence was detected with a maximum in 5-10 sec after the addition of a platelet-activating factor. In patients with bronchial asthma tolerant to aspirin, platelet activation factor did not induce chemiluminescence irrespective of incubation with acetylsalicylic acid.

Subjects

ASTHMA treatment; ASPIRIN; CHEMILUMINESCENCE; LAPAROSCOPIC surgery; ABDOMINAL surgery

Publication

Bulletin of Experimental Biology & Medicine, 2017, Vol 164, Issue 1, p36

ISSN

0007-4888

Publication type

Academic Journal

DOI

10.1007/s10517-017-3921-9