Title: Tripeptides Restore the Number of Neuronal Spines under Conditions of In Vitro Modeled Alzheimer's Disease.
Authors: Kraskovskaya, N.; Kukanova, E.; Lin'kova, N.; Popugaeva, E.; Khavinson, V.
Abstract: In primary culture of mouse hippocampal neurons, peptide EDR (200 ng/ml) under conditions of amyloid synaptotoxicity (a model of Alzheimer's disease) increased the number of mushroom spines by 71% and returned this parameter to the normal level. Under the same conditions, tripeptide KED (200 ng/ml) increased the number of mushroom spines in hippocampal neurons by 20%. Tripeptide EDR can be recommended for further experimental study as a candidate neuroprotective agent for prevention and treatment of Alzheimer's disease.
Subjects: TRIPEPTIDES; ALZHEIMER'S disease treatment; BASAL ganglia diseases; ALZHEIMER'S disease; APOLIPOPROTEIN E4
Publication: Bulletin of Experimental Biology & Medicine, 2017, Vol 163, Issue 4, p550
ISSN: 0007-4888
Publication type: Academic Journal
DOI: 10.1007/s10517-017-3847-2

Tripeptides Restore the Number of Neuronal Spines under Conditions of In Vitro Modeled Alzheimer's Disease.

Kraskovskaya, N.; Kukanova, E.; Lin'kova, N.; Popugaeva, E.; Khavinson, V.