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- Title
Evaluation of the Hepatoprotective Effect of L-Ascorbate 1-(2-Hydroxyethyl)-4,6-Dimethyl-1,2-Dihydropyrimidine-2-One Upon Exposure to Carbon Tetrachloride.
- Authors
Vyshtakalyuk, A.; Nazarov, N.; Zobov, V.; Abdulkhakov, S.; Minnekhanova, O.; Semenov, V.; Galyametdinova, I.; Cherepnev, G.; Reznik, V.
- Abstract
Hepatoprotective properties of a new pyrimidine derivative - L-ascorbate 1-(2-hydroxyethyl)-4,6-dimethyl-1,2-dihydropyrimidine-2-one, synthesized on the basis Xymedon, were assessed in white rats exposed to CCl4. The compound under study administered prior to exposure to CCl reduced the deviation of biochemical parameters from reference values and severity of structural and morphological changes in liver, when compared to the control. Hepatoprotective properties of the studied compound were more pronounced than those of Xymedon.
- Subjects
PYRIMIDINE derivatives; ETHANES; DIHYDROPYRIMIDINE dehydrogenase; CARBON tetrachloride; LIVER
- Publication
Bulletin of Experimental Biology & Medicine, 2017, Vol 162, Issue 3, p340
- ISSN
0007-4888
- Publication type
Academic Journal
- DOI
10.1007/s10517-017-3610-8