Title: Evaluation of the Hepatoprotective Effect of L-Ascorbate 1-(2-Hydroxyethyl)-4,6-Dimethyl-1,2-Dihydropyrimidine-2-One Upon Exposure to Carbon Tetrachloride.
Authors: Vyshtakalyuk, A.; Nazarov, N.; Zobov, V.; Abdulkhakov, S.; Minnekhanova, O.; Semenov, V.; Galyametdinova, I.; Cherepnev, G.; Reznik, V.
Abstract: Hepatoprotective properties of a new pyrimidine derivative - L-ascorbate 1-(2-hydroxyethyl)-4,6-dimethyl-1,2-dihydropyrimidine-2-one, synthesized on the basis Xymedon, were assessed in white rats exposed to CCl4. The compound under study administered prior to exposure to CCl reduced the deviation of biochemical parameters from reference values and severity of structural and morphological changes in liver, when compared to the control. Hepatoprotective properties of the studied compound were more pronounced than those of Xymedon.
Subjects: PYRIMIDINE derivatives; ETHANES; DIHYDROPYRIMIDINE dehydrogenase; CARBON tetrachloride; LIVER
Publication: Bulletin of Experimental Biology & Medicine, 2017, Vol 162, Issue 3, p340
ISSN: 0007-4888
Publication type: Academic Journal
DOI: 10.1007/s10517-017-3610-8

Evaluation of the Hepatoprotective Effect of L-Ascorbate 1-(2-Hydroxyethyl)-4,6-Dimethyl-1,2-Dihydropyrimidine-2-One Upon Exposure to Carbon Tetrachloride.

Vyshtakalyuk, A.; Nazarov, N.; Zobov, V.; Abdulkhakov, S.; Minnekhanova, O.; Semenov, V.; Galyametdinova, I.; Cherepnev, G.; Reznik, V.