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- Title
Role Sympathetic Autonomic Nervous System in the Regulation of Immune Response during Myasthenia.
- Authors
Lantsova, V.; Sepp, E.; Kozlovsky, A.
- Abstract
In 12 patients with myasthenia, the content of β-adrenoreceptors on the cell surface and activity of intracellular lymphocytic enzymes were determined by EIA and biochemical methods, respectively. In comparison with the normal, these patients demonstrated pronounced elevation in the content of β-adrenoreceptors and significant changes in activity of lymphocytic enzymes. In 10 of 12 patients, administration of the agonists to β-adrenoreceptors resulted in health improvement accompanied by normalization of EMG and immunobiochemical indices. Our findings suggest that intra- and intercellular signaling pathways and their modification can serve as potential targets for the therapy.
- Subjects
ENZYMES; ADRENERGIC receptors; MYASTHENIA gravis; LYMPHOCYTES; CELL membranes
- Publication
Bulletin of Experimental Biology & Medicine, 2011, Vol 151, Issue 3, p353
- ISSN
0007-4888
- Publication type
Academic Journal
- DOI
10.1007/s10517-011-1328-6