The first reactor tests and post-reactor studies of fuel elements with cladding made from the zirconium alloys E-636M, E-635opt, and E-635M1, developed at VNIINM, have been conducted. The purpose of the studies was to search for alloys of the type E-635 that surpass the base alloy in terms of resistance to corrosion and hydration. The studies make it possible to recommend the alloys E-635M and E-635opt for use as cladding of the fuel elements in extended-life cores.