Results
Title

Serum- and glucocorticoid-inducible kinase 1 in the regulation of renal and extrarenal potassium transport.

Authors

Lang, Florian; Vallon, Volker

Abstract

Serum- and glucocorticoid inducible-kinase 1 (SGK1) is an early gene transcriptionally upregulated by cell stress such as cell shrinkage and hypoxia and several hormones including gluco- and mineralocorticoids. It is activated by insulin and growth factors. SGK1 is a powerful regulator of a wide variety of channels and transporters. The present review describes the role of SGK1 in the regulation of potassium (K) channels, K transporters and K homeostasis. SGK1-regulated K channels include renal outer medullary K channel, Kv1.3, Kv1.5, KCNE1/KCNQ1, KCNQ4 and, via regulation of calcium (Ca) entry, Ca-sensitive K channels. SGK1-sensitive transporters include sodium-potassium-chloride cotransporter 2 and sodium/potassium-adenosine triphosphatase. SGK1-dependent regulation of K channels and K transport contributes to the stimulation of renal K excretion following high K intake, to insulin-induced cellular K uptake and hypokalemia, to inhibition of insulin release by glucocorticoids, to stimulation of mast cell degranulation and gastric acid secretion, and to cardiac repolarization. Thus, SGK1 has a profound effect on K homeostasis and on a multitude of K-sensitive cellular functions.

Subjects

GLUCOCORTICOIDS; SERUM; PROTEIN kinases; PHYSIOLOGICAL effects of potassium; GENETIC regulation; HYPOXEMIA; ALDOSTERONE; MAST cells; PANCREATIC beta cells; GASTRIC acid

Publication

Clinical & Experimental Nephrology, 2012, Vol 16, Issue 1, p73

ISSN

1342-1751

Publication type

Academic Journal

DOI

10.1007/s10157-011-0488-z