We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Factors influencing cardiovascular risk following termination of glucocorticoid therapy for nephrotic syndrome.
- Authors
Nakamura, Akio; Niimi, Ryo; Kurosaki, Kumiko; Yanagawa, Yukishige
- Abstract
Background: This study attempted to identify the cardiovascular risk factors associated with retention of excess weight following termination of glucocorticoid therapy in children with nephrotic syndrome. Methods: We performed a retrospective study of 30 Japanese children (18 males, 12 females, aged 1-14 years) who had been treated with glucocorticoids for steroid-sensitive nephrotic syndrome and 32 control children (17 males, 15 females, aged 1-15 years). The subjects receiving glucocorticoid therapy were divided into a retention group ( n = 14) or a reduction group ( n = 16) on the basis of the presence or absence of a maintained body mass index (BMI) following glucocorticoid termination. BMI z-scores, age, gender, blood pressure, serum total cholesterol levels (T-cho), and the dose and duration of glucocorticoid exposure were evaluated in each group during the study period. Results: The retention group had a significantly ( P < 0.05) increased dose and duration of glucocorticoid exposure, and of T-cho at the time of last visit compared with the control or reduction group. Moreover, logistic regression analysis showed that the adjusted odds ratio for T-cho at the time of last visit in the retention group was significantly higher ( P < 0.05) relative to the reduction group. Conclusion: Retention of excess weight during the period of remission from nephrotic syndrome following cessation of glucocorticoid therapy was related to the dose and duration of glucocorticoid exposure and was associated with hyperlipidemia, which might enhance cardiovascular risk.
- Subjects
GLUCOCORTICOIDS; NEPHROTIC syndrome in children; BODY mass index; BLOOD pressure; LOGISTIC regression analysis
- Publication
Clinical & Experimental Nephrology, 2010, Vol 14, Issue 5, p457
- ISSN
1342-1751
- Publication type
Academic Journal
- DOI
10.1007/s10157-010-0317-9