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- Title
Efficacy of laser treatment for onychomycotic nails: a systematic review and meta-analysis of prospective clinical trials.
- Authors
Yeung, Kelvin; Ortner, Vinzent Kevin; Martinussen, Torben; Paasch, Uwe; Haedersdal, Merete
- Abstract
Laser therapy for onychomycosis is emerging but its efficacy remains unestablished. To examine current evidence on efficacy of laser treatment of onychomycosis. A systematic review and one-arm meta-analysis, including all prospective clinical trials, identified on PubMed, Cochrane Library, and EMBASE databases. Trials with participants as unit of analysis (UOA), n = 13, were analyzed separately from trials with nails as UOA, n = 7. Summary proportions and 95% confidence intervals (95% CI) were calculated. Outcomes were mycological cure, clinical improvement, or complete cure. Twenty-two prospective trials (four randomized controlled trials and 18 uncontrolled trials) with a total of 755 participants were analyzed. Summary proportions with 95% CI for participants as UOA were mycological cure 70.4%, 95% CI 52.2-83.8%; clinical improvement 67.2%, 95% CI 43.2-84.7%; and complete cure 7.2%, 95% CI 1.9-23.5%. High statistical heterogeneity was detected (mycological cure I2 = 88%, P < 0.01; clinical improvement I2 = 69%, P < 0.01; complete cure I2 = 60%, P = 0.11). The current level of evidence is limited and with high heterogeneity, making it difficult to assess the true efficacy of laser treatment for onychomycosis. Larger randomized controlled trials with well-defined methodology are warranted.
- Subjects
ONYCHOMYCOSIS; MYCOLOGY; PUBMED (Online service); CLINICAL trials; META-analysis
- Publication
Lasers in Medical Science, 2019, Vol 34, Issue 8, p1513
- ISSN
0268-8921
- Publication type
Academic Journal
- DOI
10.1007/s10103-019-02802-8