Results
Title

Antimicrobial resistance in Clostridioides difficile.

Authors

O'Grady, Keeley; Knight, Daniel R.; Riley, Thomas V.

Abstract

Antimicrobial resistance (AMR) in Clostridioides difficile remains a significant threat to global healthcare systems, not just for the treatment of C. difficile infection (CDI), but as a reservoir of AMR genes that could be potentially transferred to other pathogens. The mechanisms of resistance for several antimicrobials such as metronidazole and MLSB-class agents are only beginning to be elucidated, and increasingly, there is evidence that previously unconsidered mechanisms such as plasmid-mediated resistance may play an important role in AMR in this bacterium. In this review, the genetics of AMR in C. difficile will be described, along with a discussion of the factors contributing to the difficulty in clearly determining the true burden of AMR in C. difficile and how it affects the treatment of CDI.

Subjects

CLOSTRIDIOIDES difficile; DRUG resistance in microorganisms; COLISTIN; GENETICS; PLASMIDS; PHENOTYPES; METRONIDAZOLE

Publication

European Journal of Clinical Microbiology & Infectious Diseases, 2021, Vol 40, Issue 12, p2459

ISSN

0934-9723

Publication type

Academic Journal

DOI

10.1007/s10096-021-04311-5