Association of variants in microRNA with Parkinson's disease in Chinese Han population.

Li, Fang; Liu, Han; Cheng, Yuan; Yang, Jing; Liu, Yutao; Wang, Yanlin; Yang, Zhihua; Shi, Changhe; Xu, Yuming

MicroRNAs (miRNAs) are short RNAs regulating gene expression and may participate in pathogenesis of various diseases. Recently, rs897984:T > C in miR-4519 and rs11651671:A > G in miR-548at-5p have been reported that associate with Parkinson's disease (PD). However, to our knowledge, there is no further evidence regarding this finding. Herein, we performed a case-control study of 546 PD patients and 550 healthy controls to genotype the two single-nucleotide polymorphisms (SNPs) to assess their associations with PD. The results showed that rs897984 (OR value for C allele = 0.851, 95% CI 0.603-1.201, P = 0.358) in miR-4519 and rs11651671 (OR value for G allele = 1.405, 95% CI 0.927-2.131, P = 0.107) in miR-548at-5p were not associated to PD, which suggest they may not contribute to the gene susceptibility of PD at least in Chinese Han population. More evidences from larger sample size and other ethnic populations are still needed to illustrate the association between miRNAs and PD.

PARKINSON'S disease diagnosis; MICRORNA; GENE expression; SINGLE nucleotide polymorphisms; CHINESE people; DISEASES; ASIANS; DISEASE susceptibility; GENETIC polymorphisms; GENETIC techniques; NONPARAMETRIC statistics; PARKINSON'S disease; RESEARCH funding; RNA; RETROSPECTIVE studies; CASE-control method; GENOTYPES

Neurological Sciences, 2018, Vol 39, Issue 2, p353

1590-1874

Academic Journal

10.1007/s10072-017-3210-4