Acute Lymphoblastic Leukemia with Hypereosinophilia: Report of a Case with 5q Deletion and Review of the Literature.

Wynn, Tung T.; Heerema, Nyla A.; Hammond, Sue; Ranalli, Mark; Kahwash, Samir B.

Peripheral blood eosinophilia as a presentation of acute lymphoblastic leukemia (ALL) has only rarely been reported. The eosinophilia is thought to be a non neoplastic reaction to the neoplastic lympho blasts. We present the case of a 5-year-old girl who developed peripheral hyper eosinophilia with no circulating blasts prior to her diagnosis of B-cell lineage ALL. Cytogenetics study showed a hyper diploid blast population with 5q deletion. Persistent peripheral hypereosinophilia should always be fully investigated, the possibility of a malignancy including ALL needs to be excluded, even in the absence of peripheral cytopenias and circulating blasts.

LYMPHOBLASTIC leukemia; EOSINOPHILIA; KARYOTYPES; B cells; CYTOGENETICS; DIAGNOSIS

Pediatric & Developmental Pathology, 2003, Vol 6, Issue 6, p558

1093-5266

Academic Journal

10.1007/s10024-003-2019-8