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- Title
Chlamydia pneumoniae and Helicobacter pylori IgG seropositivities are not predictors of osteoporosis-associated bone loss: a prospective cohort study.
- Authors
Kalantarhormozi, Mohammad; Assadi, Majid; Vahdat, Katayoun; Asadipooya, Kamyar; Ostovar, Afshin; Raissi, Katayoun; Darabi, Hossein; Farrokhi, Shokrollah; Dobaradaran, Sina; Farrokhnia, Maryam; Nabipour, Iraj; Kalantarhormozi, Mohammad Reza
- Abstract
The potential link between infection with Chlamydia pneumoniae or Helicobacter pylori and osteoporosis has not been investigated in population-based longitudinal studies. A total of 250 healthy postmenopausal women who participated in a prospective cohort study were evaluated for IgG antibodies directed against C. pneumoniae and H. p ylori, osteoprotegerin (OPG), the receptor activator of nuclear factor kappa B ligand (RANKL), CrossLaps, and osteocalcin. Bone mineral density (BMD) was measured at the femoral neck and lumbar spine at baseline and at follow-up 5.8 years later. There were no significant differences in age-adjusted bone turnover markers, OPG, RANKL, the RANKL/OPG ratio, and BMD between the C. p neumoniae and H. p ylori IgG seropositive and seronegative subjects (P > 0.05). Neither C. p neumoniae nor H. p ylori IgG seropositivity was associated with age-and body mass index-adjusted BMD at the femoral neck and lumbar spine or bone loss at the 5.8-year follow-up. In logistic regression analysis, neither C. p neumoniae nor H. p ylori IgG seropositivities predicted incident lumbar or spine osteoporosis 5.8 years later. In conclusion, neither C. p neumoniae nor H. p ylori IgG seropositivity was associated with bone turnover markers, the RANKL/OPG ratio, BMD, or bone loss in postmenopausal women. In addition, chronic infection with C. p neumoniae or H. p ylori did not predict incident osteoporosis among this group of women.
- Subjects
CHLAMYDOPHILA pneumoniae infections; GRAM-negative bacteria; VITAMIN D deficiency; CONNECTIVE tissues; FEMALE athlete triad (Syndrome); BACK; FEMUR neck; HELICOBACTER diseases; HELICOBACTER pylori; IMMUNOGLOBULINS; LONGITUDINAL method; OSTEOPOROSIS; SPINE; CHLAMYDOPHILA pneumoniae; CHLAMYDOPHILA infections; BODY mass index; BACTERIAL antibodies
- Publication
Journal of Bone & Mineral Metabolism, 2016, Vol 34, Issue 4, p422
- ISSN
0914-8779
- Publication type
Academic Journal
- DOI
10.1007/s00774-015-0688-9