Title: Temperament profiles, 5-HT2A genotype, and response to treatment with SSRIs in major depression.
Authors: Andre, Kadri; Kampman, Olli; Setälä-Soikkeli, Eija; Viikki, Merja; Poutanen, Outi; Nuolivirta, Timo; Mononen, Nina; Lehtimäki, Terho; Leinonen, Esa; Illi, Ari
Abstract: Variation in antidepressive medication response according to 5- HT2A genotype has been reported in several studies. Temperament has been proposed to be one of the vulnerability factors in mood and anxiety disorders. We studied temperament profiles of 98 patients with major depression and explored the interaction between Temperament and Character Inventory (TCI) temperament dimensions, 5- HT2A genotype (SNPs rs6311, rs6313 and rs7997012) and treatment response. No interactive effects for TCI temperament dimensions and 5- HT2A genotypes on antidepressive treatment response were found.
Subjects: CELL receptors; GENOTYPE-environment interaction; MENTAL depression; ANTIDEPRESSANTS; TEMPERAMENT; PHARMACOGENOMICS; AFFECTIVE disorders
Publication: Journal of Neural Transmission, 2010, Vol 117, Issue 12, p1431
ISSN: 0300-9564
Publication type: Academic Journal
DOI: 10.1007/s00702-010-0512-6

Temperament profiles, 5-HT2A genotype, and response to treatment with SSRIs in major depression.

Andre, Kadri; Kampman, Olli; Setälä-Soikkeli, Eija; Viikki, Merja; Poutanen, Outi; Nuolivirta, Timo; Mononen, Nina; Lehtimäki, Terho; Leinonen, Esa; Illi, Ari