Effective prophylaxis regimens against Cutibacterium acnes in neurosurgery.

D'Alessandris, Quintino Giorgio; Scoppettuolo, Giancarlo; Giordano, Martina; Della Pepa, Giuseppe Maria; Mattogno, Pier Paolo; Sturiale, Carmelo Lucio; Olivi, Alessandro

To conclude, these evidences should prompt a change in preoperative antibiotic prophylaxis regimen towards cefuroxime, not only where penicillins are still used but also in those many countries where cefazolin is currently recommended. This article is part of the Topical Collection on Infection Dear Editor, We read with interest the work by Skyrman et al. [[8]], reporting on the reduction of surgical site infections (SSIs) in brain tumor surgery in a large Swedish academic neuro-oncological center, following a change in antibiotic prophylaxis from cloxacillin to cefuroxime. Cefuroxime, as a second-generation cephalosporin, has a stronger activity against gram-negative and anaerobic bacteria than penicillins and first-generation cephalosporins like cefazolin [[1]].

NEUROSURGERY; CUTIBACTERIUM acnes; CENTRAL nervous system infections; PREVENTIVE medicine; GRAM-negative anaerobic bacteria; ANTIBIOTIC prophylaxis

Acta Neurochirurgica, 2021, Vol 163, Issue 10, p2697

0001-6268

Academic Journal

10.1007/s00701-021-04769-4