Pulmonary pleomorphic carcinoma producing granulocyte-macrophage colony-stimulating factor: report of a case.

Fukutomi, Toshinori; Kohno, Mitsutomo; Izumi, Yotaro; Watanabe, Masazumi; Hayashi, Yuichiro; Nomori, Hiroaki

We report a case of lung cancer producing granulocyte-macrophage colony-stimulating factor (GM-CSF). The patient, a 55-year-old woman, was found to have leukocytosis (leukocytes 28.8 × 10/mm) with eosinophilia (eosinophils 24.5%) without any evidence of infection or allergy. The serum concentration of GM-CSF was elevated to 44 pg/ml (normal range <2.0 pg/ml), which might have induced the leukocytosis and eosinophilia. We performed left pneumonectomy and diagnosed a pleomorphic carcinoma with p-T2bN0M0, based on histological examination of the resected tumor. Immunohistochemical examination revealed GM-CSF. The serum level of GM-CSF decreased to within the normal range 8 days after surgery. At the time of writing, 16 months after the surgery, she was alive without disease. To our knowledge, this represents the first case report of a GM-CSF-producing tumor effectively treated by surgical resection.

GRANULOCYTE-macrophage colony-stimulating factor; LUNG cancer; LEUCOCYTOSIS; EOSINOPHILIA; IMMUNOHISTOCHEMISTRY

Surgery Today, 2012, Vol 42, Issue 3, p288

0941-1291

Academic Journal

10.1007/s00595-011-0043-2