Works matching DE "DRUG target"

Results: 5000

Inhibition of p38-MK2 pathway enhances the efficacy of microtubule inhibitors in breast cancer cells.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.104859

By:

Yu-Chia Chen;
Mamoru Takada;
Aerica Nagornyuk;
Muhan Yu;
Hideyuki Yamada;
Takeshi Nagashima;
Masayuki Ohtsuka;
DeLuca, Jennifer G.;
Markus, Steven M.;
Motoki Takaku;
Aussie Suzuki

Publication type:

Article

Protective role of Angiogenin in muscle regeneration in amyotrophic lateral sclerosis: Diagnostic and therapeutic implications.

Published in:

Brain Pathology, 2025, v. 35, n. 4, p. 1, doi. 10.1111/bpa.13328

By:

Fabbrizio, Paola;
Baindoor, Sharada;
Margotta, Cassandra;
Su, Junyi;
Morrissey, Elena P.;
Woods, Ina;
Hogg, Marion C.;
Vianello, Sara;
Venø, Morten T.;
Kjems, Jørgen;
Sorarù, Gianni;
Bendotti, Caterina;
Prehn, Jochen H. M.;
Nardo, Giovanni

Publication type:

Article

Identification of therapeutic targets in lung adenocarcinoma using Mendelian randomization and multi-omics.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02835-2

By:

Li, Yue;
Ma, Keru;
Wang, Hao;
Liu, Zongying;
Li, Zhuying

Publication type:

Article

Elucidating Ras protein as a dual therapeutic target for inflammation and cancer: a review.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02783-x

By:

Nandan, Parmar Keshri;
Sivaraman, Jayanthi

Publication type:

Article

Current cutting-edge omics techniques on musculoskeletal tissues and diseases.

Published in:

Bone Research, 2025, v. 13, n. 1, p. 1, doi. 10.1038/s41413-025-00442-z

By:

Li, Xiaofei;
Fang, Liang;
Zhou, Renpeng;
Yao, Lutian;
Clayton, Sade W.;
Muscat, Samantha;
Kamm, Dakota R.;
Wang, Cuicui;
Liu, Chuan-Ju;
Qin, Ling;
Tower, Robert J.;
Karner, Courtney M.;
Guilak, Farshid;
Tang, Simon Y.;
Loiselle, Alayna E.;
Meyer, Gretchen A.;
Shen, Jie

Publication type:

Article

Mir-509-3p targets SLC25A13 to regulate ferroptosis and protect retinal endothelial cells in diabetic retinopathy.

Published in:

Acta Diabetologica, 2025, v. 62, n. 6, p. 831, doi. 10.1007/s00592-024-02400-3

By:

Ren, Meiqing;
Xu, Qian;
Luan, Jie;
Ni, Yan;
Xie, Bo

Publication type:

Article

Lactate metabolism-related genes serve as potential biomarkers for predicting gastric cancer progression and immunotherapy.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02782-y

By:

Yuan, Mingjie;
Li, Xuekai;
Song, Xuanli;
Chen, Xiaowei;
Wang, Yunshan;
Han, Shuyi;
Ni, Yang;
Liu, Duanrui

Publication type:

Article

Gut Microbiota in Lactose Intolerance: A Mendelian Randomization Study on Microbial Mechanisms and Potential Links to Tumor Inflammatory Microenvironments.

Published in:

Mediators of Inflammation, 2025, v. 2025, p. 1, doi. 10.1155/mi/8181816

By:

Xie, Ya;
Cao, Qiongjiao;
Huang, Zhen;
Zou, Xin;
Liu, Hengrui

Publication type:

Article

Study on DNA Damage Gene in Spermatogonial Stem Cells from Idiopathic Nonobstructive Azoospermia: A Bioinformatics Investigation Based on scRNA-seq Data.

Published in:

Cytogenetic & Genome Research, 2025, v. 165, n. 1, p. 9, doi. 10.1159/000545275

By:

Wang, Yi;
Weng, Yiming;
Wang, Yanqiu;
Xiang, Jun;
Le, Wei

Publication type:

Article

A retrospective comparative study: Novel diagnostical markers of inflammation and cardiovascular risk of bipolar disorder and manic episode.

Published in:

Annals of Medical of Research, 2025, v. 32, n. 5, p. 199, doi. 10.5455/annalsmedres.2025.01.019

By:

Tozoglu, Elif Ozcan

Publication type:

Article

RETRACTION: Identification of Potential Therapeutic Targets for Breast Cancer Using Mendelian Randomization Analysis and Drug Target Prediction.

Published in:: 2025
Publication type:: Correction Notice

RETRACTED: RSPO2‐associated mitochondrial metabolism defines molecular subtypes with distinct clinical and immune features in esophageal cancer.

Published in:

Environmental Toxicology, 2025, v. 40, n. 7, p. E124, doi. 10.1002/tox.24209

By:

Peng, Quanzhou;
Cao, Tianfeng;
Yang, Xue;
Ye, Zhujia;
Wang, Jun;
Chen, Shang;
Yu, Yanqi;
Yu, Yingdian;
Xue, Wenyuan;
Chen, Zhiwei;
Fan, Jianbing

Publication type:

Article

An advanced toolset to manipulate and monitor subcellular phosphatidylinositol 3,5-bisphosphate.

Published in:

Journal of Cell Biology, 2025, v. 224, n. 6, p. 1, doi. 10.1083/jcb.202408158

By:

Pemberton, Joshua G.;
Barlow-Busch, Isobel;
Jenkins, Meredith L.;
Parson, Matthew A. H.;
Sarnyai, Farkas;
Bektas, Seyma Nur;
Yeun Ju Kim;
Heuser, John E.;
Burke, John E.;
Balla, Tamas

Publication type:

Article

The Abelson kinase and the Nedd4 family E3 ligases co-regulate Notch trafficking to limit signaling.

Published in:

Journal of Cell Biology, 2025, v. 224, n. 6, p. 1, doi. 10.1083/jcb.202407066

By:

Miranda-Alban, Julio;
Sanchez-Luege, Nicelio;
Valbuena, Fernando M.;
Rangel, Chyan;
Rebay, Ilaria

Publication type:

Article

PPARγ/β/δ Agonists Can Ameliorate Dextran Sodium Sulfate–Induced Colitis and Modulate Gut Microbiota.

Published in:

Journal of Gastroenterology & Hepatology, 2025, v. 40, n. 6, p. 1536, doi. 10.1111/jgh.16929

By:

Li, Jian‐Hong;
Xu, Jing;
Hu, Jin‐Xia;
Xu, Hao‐Ming;
Guo, Xue;
Zhang, Yan;
Xu, Jing‐Kui;
Huang, Chen;
Nie, Yu‐Qiang;
Zhou, You‐Lian

Publication type:

Article

Causal Associations Between Lipids, NPC1L1, and Liver Cancer Risk: Insights From Mendelian Randomization and Bioinformatics.

Published in:

Journal of Gastroenterology & Hepatology, 2025, v. 40, n. 6, p. 1602, doi. 10.1111/jgh.16897

By:

Guo, Xiaoyan;
Wu, Lili;
Lai, Jing;
Wu, Yuankai;
Chen, Dianke

Publication type:

Article

"A REVIEW ON MICROEMULSION AND MICROSPHERE : A PROMISING OPTIMIZING TECHNIQUE FOR ADVANCED DRUG DELIVERY SYSTEM".

Published in:

Bulletin of Pure & Applied Sciences-Zoology, 2024, v. 43, p. 641

By:

Avinash, Chavan;
Kulkarni, A. S.;
Phalake, R. A.;
Sawant, Prachi;
Bade, Omkesh;
Kandurkar, Prafull;
Patil, Prajakta;
Sawant, Pramod

Publication type:

Article

Albendazole specifically disrupts microtubules and protein turnover in the tegument of the cestode Mesocestoides corti.

Published in:

PLoS Pathogens, 2025, v. 21, n. 6, p. 1, doi. 10.1371/journal.ppat.1013221

By:

Guarnaschelli, Inés;
Koziol, Uriel

Publication type:

Article

KMT2A重排急性髓系白血病的研究进展.

Published in:

Journal of Nanjing Medical University: Natural Sciences, 2025, v. 45, n. 5, p. 718, doi. 10.7655/NYDXBNSN241470

By:

李佳欣;
陶善东;
于亮

Publication type:

Article

Anti-atherosclerotic effects and molecular targets of salvianolic acids from Salvia miltiorrhiza Bunge.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1574086

By:

Liang, Qingzhi;
Liu, Xiaoqin;
Xu, Xin;
Chen, Zhengtao;
Luo, Ting;
Su, Yi;
Xie, Hongyan;
Gao, Hong;
Xie, Chunguang

Publication type:

Article

Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide.

Published in:

Medicinal Research Reviews, 2025, v. 45, n. 4, p. 1275, doi. 10.1002/med.22116

By:

Bauer, Nicola;
Mao, Qiyue;
Vashistha, Aditi;
Seshadri, Anupamaa;
Nancy Du, Yi‐Chieh;
Otterbein, Leo;
Tan, Chalet;
de Caestecker, Mark P.;
Wang, Binghe

Publication type:

Article

Proteomics: An In‐Depth Review on Recent Technical Advances and Their Applications in Biomedicine.

Published in:

Medicinal Research Reviews, 2025, v. 45, n. 4, p. 1021, doi. 10.1002/med.22098

By:

Liang, Jing;
Tian, Jundan;
Zhang, Huadong;
Li, Hua;
Chen, Lixia

Publication type:

Article

Innovative Therapieansätze in der Rheumatologie.

Published in:

Zeitschrift für Rheumatologie, 2025, v. 84, n. 5, p. 387, doi. 10.1007/s00393-025-01658-4

By:

Singla, Abhinav;
Iking-Konert, Christof;
Kellersmann, Carolin;
Mougiakakos, Dimitrios;
Feist, Eugen

Publication type:

Article

UXT enhances melanoma proliferation, migration, and invasion through modulation of the P53 signaling pathway.

Published in:

Cell Division, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13008-025-00151-3

By:

Xiong, Kaifen;
Wang, Chong;
Hu, Bingqian;
Zhang, Jianglin;
Qi, Min

Publication type:

Article

Isoflurane activates the type 1 ryanodine receptor to induce anesthesia in mice.

Published in:

PLoS Biology, 2025, v. 23, n. 6, p. 1, doi. 10.1371/journal.pbio.3003172

By:

Kanaya, Hiroyuki J.;
Kuwajima, Ken;
Ito, Yuko;
Shinohara, Yuta;
Okubo, Yohei;
Shiono, Shinnosuke;
Tatsuki, Fumiya;
Ohno, Rei-ichiro;
Ukai, Hideki;
Ukai-Tadenuma, Maki;
Sumiyama, Kenta;
Fujishima, Hiroshi;
Yamada, Rikuhiro G.;
Tone, Daisuke;
Kiyonari, Hiroshi;
Kikuchi, Masaki;
Umehara, Takashi;
Murayama, Takashi;
Kanemaru, Kazunori;
Iino, Masamitsu

Publication type:

Article

Bibliometric analysis of MXRA7 gene research trajectory: trends and insights (2015–2024).

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02824-5

By:

Zhang, Huihui;
Shen, Ying;
Bai, Peijian;
Wu, Xiaorui;
Li, Ping;
Wang, Ting

Publication type:

Article

PSORIASIS - WHAT'S NEW? SHORT SYNOPSIS.

Published in:

Dermatovenerologia Journal, 2025, v. 70, n. 1, p. 33

By:

MIHALACHE, DANIELA;
MEHEDINȚI, MIHAELA-CEZARINA;
HÎNCU, MARIA-ANDRADA;
ONOFREI, ANDREEA;
CHELMU-VODĂ, CRISTINA;
GURĂU, ALINA-MIHAELA;
GAVRILIȚĂ, ELENA;
TATU, ALIN LAURENȚIU

Publication type:

Article

Unlocking Asthma Remission: Key Insights From an Expert Roundtable Discussion.

Published in:

Respirology, 2025, v. 30, n. 6, p. 466, doi. 10.1111/resp.70047

By:

Thomas, Dennis;
Lewthwaite, Hayley;
Gibson, Peter G.;
Majellano, Eleanor;
Clark, Vanessa;
Fricker, Michael;
Hamada, Yuto;
Anderson, Gary P.;
Backer, Vibeke;
Bardin, Philip;
Beasley, Richard;
Chien, Jimmy;
Farah, Claude S.;
Harrington, John;
Harvey, Erin;
Hew, Mark;
Holland, Anne E.;
Jenkins, Christine;
Katelaris, Constance H.;
Katsoulotos, Gregory

Publication type:

Article

Evaluating metabolome-wide causal effects on risk for psychiatric and neurodegenerative disorders.

Published in:

BMC Medicine, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12916-025-04129-4

By:

Gilchrist, Lachlan;
Mutz, Julian;
Hysi, Pirro;
Legido-Quigley, Cristina;
Kõks, Sulev;
Lewis, Cathryn M.;
Proitsi, Petroula

Publication type:

Article

Molecular docking of quercetin: a promising approach for the development of new anti-inflammatory and analgesic drugs.

Published in:

Natural Product Research, 2025, v. 39, n. 11, p. 3202, doi. 10.1080/14786419.2024.2333053

By:

Ettitaou, Amina;
Kabdy, Hamid;
Oubella, Khadija;
Raoui, Karima;
Oubahmane, Mehdi;
Aboufatima, Rachida;
Elyazouli, Loubna;
Garzoli, Stefania;
Chait, Abderrahman

Publication type:

Article

Radiotheranostic landscape: A review of clinical and preclinical development.

Published in:

European Journal of Nuclear Medicine & Molecular Imaging, 2025, v. 52, n. 7, p. 2685, doi. 10.1007/s00259-025-07103-7

By:

Tran, Ha H.;
Yamaguchi, Aiko;
Manning, H. Charles

Publication type:

Article

Loss of UBE3A impacts both neuronal and non-neuronal cells in human cerebral organoids.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-08262-x

By:

Estridge, R. Chris;
Yagci, Z. Begum;
Sen, Dilara;
Johnson, Tyler J.;
Kelkar, Gautami R.;
Ptacek, Travis S.;
Simon, Jeremy M.;
Keung, Albert J.

Publication type:

Article

The Alkaloid Gelsemine Reduces Aβ Peptide Toxicity by Targeting Transglutaminase Type 2 Enzyme.

Published in:

Plants (2223-7747), 2025, v. 14, n. 10, p. 1556, doi. 10.3390/plants14101556

By:

Panes-Fernández, Jessica;
Marileo, Ana M.;
Espinoza-Rubilar, Nicole;
Meza, Macarena E.;
Salgado-Martínez, Bernardita A.;
Gaete-Riquelme, Krishna;
Moraga-Cid, Gustavo;
Castro, Patricio A.;
Burgos, Carlos F.;
Fuentealba, Jorge;
Yévenes, Gonzalo E.

Publication type:

Article

Genome-Wide Analysis of Zm4CL Genes Identifies Zm4CL8 Regulating Drought and Salt Tolerance in Maize.

Published in:

Agronomy, 2025, v. 15, n. 5, p. 1100, doi. 10.3390/agronomy15051100

By:

Zhang, Ze;
Wang, Yanbin;
Li, Rong

Publication type:

Article

Shed Syndecan-4 and Its Possible Roles in Osteoarthritis.

Published in:

Biomedicines, 2025, v. 13, n. 5, p. 1037, doi. 10.3390/biomedicines13051037

By:

He, Kangping;
Ren, Haozhe;
Chen, Xiaohua;
He, Feng;
Zhang, Yueying;
Zhang, Hongyun;
Li, Feifei;
Yu, Shibin

Publication type:

Article

Transcriptomic Profiling Uncovers Molecular Basis for Sugar and Acid Metabolism in Two Pomegranate (Punica granatum) Varieties.

Published in:

Foods, 2025, v. 14, n. 10, p. 1755, doi. 10.3390/foods14101755

By:

Ke, Ding;
Zhang, Yilong;
Teng, Yingfen;
Zhao, Xueqing

Publication type:

Article

Integrating Transcriptomic and Proteomic Data: IL‐27B as a Key Protein in the Development of Septic Cardiomyopathy—A Retrospective Study.

Published in:

Immunity, Inflammation & Disease, 2025, v. 13, n. 5, p. 1, doi. 10.1002/iid3.70207

By:

Mao, Yifeng;
Chen, Qingqing;
Jiang, Yongpo;
Zhang, Xijiang;
Si, Qin;
Xu, Panpan;
Zhang, Zhongheng;
Zheng, Cheng;
Lin, Ronghai

Publication type:

Article

Molecular Targets of Oxidative Stress: Focus on Nuclear Factor Erythroid 2–Related Factor 2 Function in Leukemia and Other Cancers.

Published in:

Cells (2073-4409), 2025, v. 14, n. 10, p. 713, doi. 10.3390/cells14100713

By:

Hasan, Syed K.;
Jayakumar, Sundarraj;
Espina Barroso, Eliezer;
Jha, Anup;
Catalano, Gianfranco;
Sandur, Santosh K.;
Noguera, Nelida I.

Publication type:

Article

Nicotinamide N-Methyltransferase (NNMT) and Liver Cancer: From Metabolic Networks to Therapeutic Targets.

Published in:

Biomolecules (2218-273X), 2025, v. 15, n. 5, p. 719, doi. 10.3390/biom15050719

By:

Lai, Shi-Yan;
Zhu, Xiao-Juan;
Sun, Wei-Dong;
Bi, Shuang-Zhou;
Zhang, Chen-Ying;
Liu, An;
Li, Jiang-Hua

Publication type:

Article

Post-Translational Modifications in Multiple Myeloma: Mechanisms of Drug Resistance and Therapeutic Opportunities.

Published in:

Biomolecules (2218-273X), 2025, v. 15, n. 5, p. 702, doi. 10.3390/biom15050702

By:

Hu, Shuoyang;
Xu, Jirun;
Cui, Weiyan;
Jin, Haoran;
Wang, Xiaoyu;
Maimaitiyiming, Yasen

Publication type:

Article

Celebrating Ulrik Ringborg: Multi-Omics-Based Patient Stratification for Precision Cancer Treatment.

Published in:

Biomolecules (2218-273X), 2025, v. 15, n. 5, p. 693, doi. 10.3390/biom15050693

By:

Teleanu, Maria-Veronica;
Schneider, Annika;
Ball, Claudia R.;
Leber, Mathias Felix;
Stange, Christoph;
Krieghoff-Henning, Eva;
Beck, Katja;
Heilig, Christoph E.;
Kreutzfeldt, Simon;
Kuster, Bernhard;
Lipka, Daniel B.;
Fröhling, Stefan

Publication type:

Article

Bolstering CD8 + T Cells' Antitumor Immunity: A Promising Strategy to Improve the Response to Advanced Prostate Cancer Treatment.

Published in:

Biology (2079-7737), 2025, v. 14, n. 5, p. 544, doi. 10.3390/biology14050544

By:

Dang, Beijing;
Liang, Lixin;
Li, Zhijun;
Luo, Junli;
Zhong, Shangwei

Publication type:

Article

Comparative Analysis of Cytokine Expression Profiles in Prostate Cancer Patients.

Published in:

Biology (2079-7737), 2025, v. 14, n. 5, p. 505, doi. 10.3390/biology14050505

By:

Coelho, Karoline Brito Caetano Andrade;
Wosniaki, Denise Kusma;
Pereira, Jonatas Luiz;
Luz, Murilo;
Albrecht, Letusa;
Nardin, Jeanine Marie;
Aoki, Mateus Nobrega;
Reis, Leonardo O.;
dos Reis, Rodolfo Borges;
Zanette, Dalila Lucíola

Publication type:

Article

A Computational Approach to Identify Novel Protein Targets Uncovers New Potential Mechanisms of Action of Mirtazapine S(+) and R(−) Enantiomers in Rett Syndrome.

Published in:

Journal of Neurochemistry, 2025, v. 169, n. 5, p. 1, doi. 10.1111/jnc.70093

By:

Roggero, Ottavia Maria;
Gualandi, Nicolò;
Ciraci, Viviana;
Berutto, Vittoria;
Carosati, Emanuele;
Tongiorgi, Enrico

Publication type:

Article

Astrocyte Dysfunctions in Obsessive Compulsive Disorder: Rethinking Neurobiology and Therapeutic Targets.

Published in:

Journal of Neurochemistry, 2025, v. 169, n. 5, p. 1, doi. 10.1111/jnc.70092

By:

Gonzalez, Laurine;
Bezzi, Paola

Publication type:

Article

PKG‐Mediated Phosphorylation of TOP2A Activates HDAC to Drive Photoreceptor Cell Death in rd1 Mouse Inherited Retinal Degeneration.

Published in:

Journal of Neurochemistry, 2025, v. 169, n. 5, p. 1, doi. 10.1111/jnc.70077

By:

Dong, Yujie;
Zuo, Wandong;
Li, Yan;
Feng, Xiaoxiao;
Guo, Chunming;
Chen, Maorong;
Yan, Jie;
Hou, Chunjiang;
Peng, Hua;
Hu, Zhulin;
Liu, Hai;
Paquet‐Durand, François;
Jiao, Kangwei

Publication type:

Article

Thyroid-Stimulating Hormone: An Important Target for the Prevention of Nonalcoholic Fatty Liver Disease.

Published in:

Physiological Research, 2025, v. 74, n. 2, p. 175, doi. 10.33549/physiolres.935453

By:

Zixuan WANG;
Hanyu WANG;
Hui SUN

Publication type:

Article

The impact of gliomas on the normal brain microenvironment: a pilot study.

Published in:

Journal of Histotechnology, 2025, v. 48, n. 2, p. 93, doi. 10.1080/01478885.2024.2408505

By:

Riha, Nicole;
Moore, Jacen S.;
Criswell, Sheila

Publication type:

Article

Lipids, lipid-lowering drug target genes and pancreatic cancer: a Mendelian randomization study.

Published in:

International Journal of Clinical Pharmacy, 2025, v. 47, n. 3, p. 747, doi. 10.1007/s11096-025-01866-7

By:

Zhan, Yuxuan;
Zhang, Kai;
Fan, Yiqun;
Lin, Siyi;
Wu, Jian;
Xu, Hongxia

Publication type:

Article

Genomic landscape of biliary tract cancer and corresponding targeted treatment strategies.

Published in:

International Journal of Clinical Oncology, 2025, v. 30, n. 6, p. 1069, doi. 10.1007/s10147-025-02761-x

By:

Yamada, Daisaku;
Kobayashi, Shogo;
Doki, Yuichiro;
Eguchi, Hidetoshi

Publication type:

Article