Etomidate plus propofol versus propofol alone for sedation during gastroscopy: a randomized prospective clinical trial.

Zhou, Xiang; Li, Bi-Xi; Chen, Li-Min; Tao, Jun; Zhang, Sui; Ji, Meng; Wu, Ming-Chun; Chen, Min; Zhang, Yan-Hui; Gan, Guo-Shen; Song, Xiao-Yang

<bold>Background and Aims: </bold>Sedation with propofol alone during gastroscopy has many side effects. Etomidate has advantages in terms of circulation and respiration compared to propofol. We hypothesized that etomidate plus propofol during gastroscopy would be more safe and effective than propofol alone.<bold>Methods: </bold>Four hundred (n = 400) patients were randomly divided into a propofol group (P group) and a etomidate plus propofol group (EP group). The P group was given the first dose of 1 % propofol 1 mg/kg before gastroscopy, and the EP group was given 1 % propofol 0.5 mg/kg plus etomidate 0.1 mg/kg. Repeated doses of 10-20 mg propofol or 5-10 mg propofol plus 1-2 mg etomidate were administered to maintain an adequate level of sedation. The sedation depth was maintained by bispectral index value of 40-60.<bold>Results: </bold>The EP group had a lower incidence of systolic hypotension (13.0 vs. 32.5 %; P < 0.0001), bradycardia (8.5 vs. 16.5 %; P = 0.0226), mild hypoxemia (6.5 vs. 18.0 %; P = 0.0007), and severe hypoxemia (2.5 vs. 10.0 %; P = 0.0031) compared to the P group. Also, the satisfaction of anesthetist and gastroscopist with EP was higher than that of P group (P < 0.0001; P = 0.018, respectively).<bold>Conclusion: </bold>Etomidate plus propofol had few effects on respiration and circulation in patients undergoing gastroscopy and was more safe and effective than propofol alone.

ETOMIDATE; PROPOFOL; GASTROSCOPY; CLINICAL trials; DRUG side effects

Surgical Endoscopy & Other Interventional Techniques, 2016, Vol 30, Issue 11, p5108

1866-6817

Academic Journal

10.1007/s00464-016-4861-6