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- Title
TRPM2 mediates distruption of autophagy machinery and correlates with the grade level in prostate cancer.
- Authors
Tektemur, Ahmet; Ozaydin, Seda; Etem Onalan, Ebru; Kaya, Nalan; Kuloglu, Tuncay; Ozercan, İbrahim Hanifi; Tekin, Suat; Elyas, Halit Mohammed
- Abstract
Transient receptor potential melastatin 2 (TRPM2), a calcium-permeable ion channel, is shown as a prognostic marker candidate in prostate cancer (PCa) and an important regulator of autophagy. We aimed to determine the changes in TRPM2 and autophagic-apoptotic gene expression levels in human prostate adenocarcinomas, and to investigate the affect of TRPM2 on autophagic pathways in PC-3 cell line.
- Publication
Journal of cancer research and clinical oncology, 2019, Vol 145, Issue 5, p1297
- ISSN
1432-1335
- Publication type
Journal Article
- DOI
10.1007/s00432-019-02898-z