EBSCO Logo
Connecting you to content on EBSCOhost
Results
Title

Renal histiocytic fibrillary inclusions in a patient with new-onset proteinuria and monoclonal gammopathy.

Authors

Shrestha, Sanjivani; Malvica, Silvia; Gautam, Samir C.; Bagnasco, Serena

Abstract

This article discusses a case of a 63-year-old male with new-onset proteinuria and monoclonal gammopathy. The patient presented with chronic kidney disease and elevated serum creatinine levels. Various differential diagnoses were considered, including renal involvement by AL-type amyloidosis and light chain proximal tubulopathy. A kidney biopsy revealed the presence of proximal lambda light chain tubulopathy with light chain-storing histiocytes. The patient was subsequently diagnosed with multiple myeloma and started on treatment. This case highlights the diverse range of pathologic lesions associated with renal dysfunction in patients with monoclonal gammopathy and emphasizes the importance of kidney biopsy in the diagnosis of related diseases.

Subjects

PROTEINURIA; IMMUNOGLOBULIN light chains; LYSOSOMES; MONOCLONAL antibodies; FANCONI syndrome; DIAGNOSIS; RAYNAUD'S disease

Publication

Virchows Archiv: European Journal of Pathology, 2024, Vol 484, Issue 6, p1033

ISSN

0945-6317

Publication type

Academic Journal

DOI

10.1007/s00428-024-03815-7

EBSCO Connect | Privacy policy | Terms of use | Copyright | Manage my cookies
Journals | Subjects | Sitemap
© 2025 EBSCO Industries, Inc. All rights reserved