Pro- and anti-inflammatory cytokine responses to a 164-km road cycle ride in a hot environment.

Luk, Hui-Ying; Levitt, Danielle; Lee, Elaine; Ganio, Matthew; McDermott, Brendon; Kupchak, Brian; McFarlin, Brian; Hill, David; Armstrong, Lawrence; Vingren, Jakob; Levitt, Danielle E; Lee, Elaine C; Ganio, Matthew S; McDermott, Brendon P; Kupchak, Brian R; McFarlin, Brian K; Hill, David W; Armstrong, Lawrence E; Vingren, Jakob L

Purpose: The purpose of this study was to examine the circulating cytokine response to a recreational 164-km road cycling event in a high ambient temperature and to determine if this response was affected by self-paced exercise time to completion.Methods: Thirty-five men and five women were divided into tertiles based on time to complete the cycling event: slowest (SLOW), moderate (MOD), and fastest (FAST) finishers. Plasma samples were obtained 1-2 h before (PRE) and immediately after (IP) the event. A high-sensitivity multiplex assay kit was used to determine the concentration of plasma anti-inflammatory cytokines (IL-4, IL-5, IL-10, IL-13) and pro-inflammatory cytokines (IL-1β, IL-2, IL-6, IL-7, IL-8, IL-12, GM-CSF, IFN-γ, and TNF-α).Results: The concentration of plasma IL-10 increased significantly (p Conclusions: Completion of a 164-km cycling event induced substantial changes in circulating pro- and anti-inflammatory cytokine concentrations. Time to completion appears to have a greater influence on the systemic IL-10 response than the environmental condition; however, it is possible that a threshold for absolute intensity must be reached for environmental conditions to affect the IL-10 response to exercise. Thus, cyclists from the FAST/MOD groups appear more likely to experience an acute transient immune suppression than cyclists from the SLOW group.

ANTI-inflammatory agents; CYTOKINES; CYCLING competitions; IMMUNOSUPPRESSION; CYCLISTS; HEALTH; BIOTIC communities; CYCLING; EXERCISE; HEAT; PHYSIOLOGICAL effects of heat; INFLAMMATORY mediators; PHYSICAL fitness

European Journal of Applied Physiology, 2016, Vol 116, Issue 10, p2007

1439-6319

Academic Journal

10.1007/s00421-016-3452-5