Results
Title

In focus in HCB.

Authors

Taatjes, Douglas J.; Roth, Jürgen

Abstract

Graph In this month's editorial, we will highlight two manuscripts describing (1) a newly developed electron microscopy method to determine the precise membrane distributions of the glycerophospholipids phosphatidylserine and phosphatidylethanolamine in the obligate intracellular parasite I Toxoplasma gondii i and (2) the relationship between placental tissue 8-hydoxyguanine immunostaining (indicative of cellular oxidative stress) and fetal size at birth, placental histology, fetal sex, and other pregnancy characteristics. Thus, in I T. gondii i tachyzoites, they could detect PtdSer in the cytoplasmic and exoplasmic leaflet of both the plasma membrane and the middle membrane of the inner membrane complex, but practically nothing in the cytoplasmic leaflet of the inner membrane of the inner membrane complex. In their present study, Konishi et al. ([5]) have investigated and quantified the distribution of phosphatidylserine (PtdSer) and phosphatidylethanolamine (PtdEtn) in the cytoplasmic and exoplasmic membrane leaflets and of GM3 ganglioside as a membrane raft marker in I T. gondii i , including strains of different virulence levels.

Subjects

BIOLOGICAL specimens; FETUS; FETAL growth retardation; SMALL for gestational age; FETAL development; CHORIONIC villi; TROPHOBLAST; IMMUNOGLOBULINS

Publication

Histochemistry & Cell Biology, 2023, Vol 160, Issue 4, p277

ISSN

0948-6143

Publication type

Academic Journal

DOI

10.1007/s00418-023-02238-w