[¹⁸F]DPA-714-PET-MRI reveals pronounced innate immunity in human anti-LGI1 and anti-CASPR2 limbic encephalitis.

Roll, Wolfgang; Bauer, Jan; Dik, Andre; Mueller, Christoph; Backhaus, Philipp; Räuber, Saskia; Zinnhardt, Bastian; Gallus, Marco; Wimberley, Catriona; Körtvelyessy, Peter; Schindler, Philipp; Stenzel, Werner; Elger, Christian E.; Becker, Albert; Lewerenz, Jan; Wiendl, Heinz; Meuth, Sven G.; Schäfers, Michael; Melzer, Nico

This document, published in the Journal of Neurology, explores the use of [18F]DPA-714-PET-MRI as a diagnostic tool for autoimmune limbic encephalitis (ALE) with specific autoantibodies. The study involved two patients with these autoantibodies, and the results showed increased tracer uptake in certain areas of the brain. The study suggests that [18F]DPA-714-PET-MRI could be a valuable tool for diagnosing ALE and assessing the immune response in the brain. However, further research is needed to fully understand its potential for clinical use in ALE.

EPILEPSY; ANTI-NMDA receptor encephalitis; NATURAL immunity; ENCEPHALITIS; SCIENCE education

Journal of Neurology, 2024, Vol 271, Issue 6, p3653

0340-5354

Academic Journal

10.1007/s00415-024-12302-7