Results
Title

Predictors of Early and Late Lung Function Improvement in Severe Eosinophilic Asthma on Type2-Biologics in the PRISM Study.

Authors

Pham, Duong Duc; Lee, Ji-Hyang; Kwon, Hyouk-Soo; Song, Woo-Jung; Cho, You Sook; Kim, Hyunkyoung; Kwon, Jae-Woo; Park, So-Young; Kim, Sujeong; Hur, Gyu Young; Kim, Byung Keun; Nam, Young-Hee; Yang, Min-Suk; Kim, Mi-Yeong; Kim, Sae-Hoon; Lee, Byung-Jae; Lee, Taehoon; Kim, Min-Hye; Cho, Young-Joo; Park, ChanSun

Abstract

Background: The determinants linked to the short- and long-term improvement in lung function in patients with severe eosinophilic asthma (SEA) on biological treatment (BioT) remain elusive. Objective: We sought to identify the predictors of early and late lung function improvement in patients with SEA after BioT. Methods: 140 adult patients with SEA who received mepolizumab, dupilumab, or reslizumab were followed up for 6 months to evaluate improvement in forced expiratory volume in one second (FEV1). Logistic regression was used to determine the association between potential prognostic factors and improved lung function at 1 and 6 months of treatment. Results: More than a third of patients with SEA using BioT showed early and sustained improvements in FEV1 after 1 month. A significant association was found between low baseline FEV1 and high blood eosinophil count and sustained FEV1 improvement after 1 month (0.54 [0.37–0.79] and 1.88 [1.28–2.97] odds ratios and 95% confidence interval, respectively). Meanwhile, among patients who did not experience FEV1 improvement after 1 month, 39% exhibited improvement at 6 months follow-up. A high ACT score measured at this visit was the most reliable predictor of late response after 6 months of treatment (OR and 95% CI 1.75 [1.09–2.98]). Conclusion: Factors predicting the efficacy of biological agents that improve lung function in SEA vary according to the stage of response.

Subjects

PULMONARY eosinophilia; FORCED expiratory volume; LUNGS; ASTHMA; LOGISTIC regression analysis

Publication

Lung (0341-2040), 2024, Vol 202, Issue 1, p41

ISSN

0341-2040

Publication type

Academic Journal

DOI

10.1007/s00408-024-00670-w