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Title

Assessment of uterine enhancement rate after abdominal radical trachelectomy using dynamic contrast-enhanced magnetic resonance imaging.

Authors

Makino, Hiroshi; Kato, Hiroki; Furui, Tatsuro; Hayasaki, Yoh; Morishige, Ken-ichirou; Kanematsu, Masayuki

Abstract

Purpose: The purpose of this study was to assess uterine enhancement rate after abdominal radical trachelectomy (ART) using dynamic contrast-enhanced (DCE) magnetic resonance (MR) imaging.Methods: Ten patients with early uterine cervical cancer, who were treated by ART, were included in this study. Each patient underwent DCE MR imaging using a 3 T unit to assess uterine enhancement rate at three times (before surgery and 1 and 3 months after surgery). The radiologist calculated mean signal intensities of the anterior and posterior myometrium and also measured the signal intensities of the urine in the bladder on the same image, which was expressed as the myometrium-to-urine signal intensity ratio. In the time-intensity ratio curve, enhancement parameters (peak signal intensity ratio and peak time) of the uterine body were compared across the three MR examinations.Results: The peak signal intensity ratio was 6.96 ± 0.98 on MR examinations before surgery, 6.14 ± 0.81 1 month after surgery, and 6.26 ± 0.63 3 months after surgery (p = 0.069). The peak time was 57.6 ± 3.4 s on MR examinations before surgery, 56.4 ± 4.4 s 1 month after surgery, and 53.2 ± 8.0 s 3 months after surgery (p = 0.304). No significant differences were found in either the peak signal intensity ratio or peak time across the three MR examinations.Conclusions: That no significant decrease of uterine enhancement rate was found after surgery suggests the uterine function and fertility may be preserved after ART.

Subjects

TRACHELECTOMY; CONTRAST-enhanced magnetic resonance imaging; CERVICAL cancer patients; HUMAN fertility; MYOMETRIUM; CERVIX uteri surgery; ABDOMEN; ADENOCARCINOMA; ARTERIES; CERVIX uteri; MAGNETIC resonance imaging; SQUAMOUS cell carcinoma; CERVIX uteri tumors; CONTRAST media; FERTILITY preservation

Publication

Archives of Gynecology & Obstetrics, 2016, Vol 293, Issue 3, p625

ISSN

0932-0067

Publication type

Academic Journal

DOI

10.1007/s00404-015-3842-7

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